| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | @ | BUF | 40-41 | L | -1.5 | 50.5 | New Era Field |
| 2025-09-14 | 2 | vs | CLE | 41-17 | W | 12.5 | 46.5 | M&T Bank Stadium |
| 2025-09-22 | 3 | vs | DET | 30-38 | L | 4.5 | 53.5 | M&T Bank Stadium |
| 2025-09-28 | 4 | @ | KC | 20-37 | L | -2.5 | 48.5 | GEHA Field at Arrowhead Stadium |
| 2025-10-05 | 5 | vs | HOU | 10-44 | L | -2.5 | 41.5 | M&T Bank Stadium |
| 2025-10-12 | 6 | vs | LA | 3-17 | L | -7 | 43.5 | M&T Bank Stadium |
| 2025-10-26 | 8 | vs | CHI | 30-16 | W | 2.5 | 45.5 | M&T Bank Stadium |
| 2025-10-30 | 9 | @ | MIA | 28-6 | W | -7.5 | 51.5 | Hard Rock Stadium |
| 2025-11-09 | 10 | @ | MIN | 27-19 | W | -4.5 | 48.5 | U.S. Bank Stadium |
| 2025-11-16 | 11 | @ | CLE | 23-16 | W | -7.5 | 37.5 | FirstEnergy Stadium |
| 2025-11-23 | 12 | vs | NYJ | 23-10 | W | 14 | 44.5 | M&T Bank Stadium |
| 2025-11-27 | 13 | vs | CIN | 14-32 | L | 7 | 52.5 | M&T Bank Stadium |
| 2025-12-07 | 14 | vs | PIT | 22-27 | L | 5.5 | 43.5 | M&T Bank Stadium |
| 2025-12-14 | 15 | @ | CIN | 24-0 | W | -2.5 | 51.5 | Paycor Stadium |
| 2025-12-21 | 16 | vs | NE | 24-28 | L | 3.5 | 48.5 | M&T Bank Stadium |
| 2025-12-27 | 17 | @ | GB | 41-24 | W | 2.5 | 38.5 | Lambeau Field |
| 2026-01-04 | 18 | @ | PIT | 24-26 | L | -4.5 | 41.5 | Acrisure Stadium |
