| # | Player | Pos | Team | G | Pass yds | Pass TD | Rush yds | Rush TD | Rec | Rec yds | Rec TD | Sacks | Tackles | FP (PPR) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Cam Ward | QB | TEN | 17 | 3,169 | 15 | 159 | 2 | 186.7 | |||||
| 2 | Tony Pollard | RB | TEN | 17 | 1,082 |
| 5 |
| 33 |
| 206 |
| 185.8 |
| 3 | Chimere Dike | WR | TEN | 17 | 18 | 48 | 423 | 4 | 128.1 |
| 4 | Chig Okonkwo | TE | TEN | 17 | 56 | 560 | 2 | 1 | 124.0 |
| 5 | Elic Ayomanor | WR | TEN | 16 | 41 | 515 | 4 | 1 | 116.5 |
| 6 | Tyjae Spears | RB | TEN | 13 | 283 | 2 | 45 | 264 | 1 | 111.7 |
| 7 | Gunnar Helm | TE | TEN | 16 | 44 | 357 | 2 | 1 | 91.7 |
| 8 | Van Jefferson | WR | TEN | 14 | 29 | 350 | 1 | 70.0 |
| 9 | Calvin Ridley | WR | TEN | 7 | 17 | 303 | 47.3 |
| 10 | David Martin-Robinson | TE | TEN | 11 | 4 | 30 | 1 | 5 | 13.0 |
| 11 | James Proche | WR | TEN | 6 | 6 | 65 | 12.5 |
| 12 | Jeffery Simmons | DT | TEN | 15 | 1 | 1 | 1 | 11 | 37 | 7.1 |
| 13 | Xavier Restrepo | WR | TEN | 2 | 3 | 41 | 7.1 |
| 14 | Mason Kinsey | WR | TEN | 6 | 2 | 48 | 4 | 6.8 |
| 15 | Julius Chestnut | RB | TEN | 16 | 40 | 10 | 4.0 |
| 16 | Bryce Oliver | WR | TEN | 2 | 1 | 8 | 1 | 1.8 |
| 17 | Brandon Allen | QB | TEN | 1 | 72 | 0.9 |
| 18 | Kalel Mullings | RB | TEN | 4 | 7 | 1 | 0.7 |
| 19 | Johnny Hekker | P | TEN | 17 | 3 |
| 20 | Kevin Zeitler | G | TEN | 4 | 1 |
| 21 | Quandre Diggs | S | TEN | 8 | 16 |
| 22 | Jihad Ward | LB | TEN | 17 | 5 | 14 |
| 23 | Xavier Woods | FS | TEN | 10 | 1 | 23 |
| 24 | Kyzir White | OLB | TEN | 1 | 2 |
| 25 | Sebastian Joseph-Day | DE | TEN | 15 | 2 | 18 |
| 26 | Arden Key | LB | TEN | 12 | 4 | 9 |
| 27 | Olisaemeka Udoh | OT | TEN | 3 |
| 28 | Joey Slye | K | TEN | 16 | 3 |
| 29 | Blake Hance | OL | TEN | 1 |
| 30 | Kemon Hall | DB | TEN | 2 | 9 |
| 31 | Amani Hooker | SAF | TEN | 16 | 1 | 58 |
| 32 | Cody Barton | LB | TEN | 17 | 1 | 34 |
| 33 | Joe Bachie | LB | TEN | 8 | 12 |
| 34 | James Lynch | DT | TEN | 16 | 0.5 | 12 |
| 35 | L'Jarius Sneed | CB | TEN | 7 | 17 |
| 36 | Lloyd Cushenberry III | C | TEN | 3 |
| 37 | Dan Moore Jr. | OT | TEN | 4 | 1 |
| 38 | Kaiir Elam | CB | TEN | 11 | 21 |
| 39 | Mike Brown | SAF | TEN | 4 | 3 |
| 40 | Darrell Baker Jr. | CB | TEN | 15 | 38 |
| 41 | Jalyn Armour-Davis | CB | TEN | 10 | 16 |
| 42 | Truman Jones | LB | TEN | 5 | 1.5 | 4 |
| 43 | Jerrick Reed II | SAF | TEN | 4 | 6 |
| 44 | Erick Hallett | SAF | TEN | 3 | 12 |
| 45 | Jordan Mims | RB | TEN | 1 | 1 |
| 46 | Kendell Brooks | SAF | TEN | 6 | 11 |
| 47 | Ali Gaye | LB | TEN | 1 | 1 |
| 48 | John Ojukwu | OT | TEN | 1 |
| 49 | Peter Skoronski | OT | TEN | 4 |
| 50 | Sanoussi Kane | SAF | TEN | 3 | 3 |
| 51 | C.J. Ravenell | DE | TEN | 6 | 1 |
| 52 | James Williams | LB | TEN | 11 | 1 | 21 |
| 53 | Jaylen Harrell | LB | TEN | 15 | 4.5 | 13 |
| 54 | JC Latham | OT | TEN | 9 |
| 55 | Cedric Gray | LB | TEN | 16 | 1 | 94 |
| 56 | T'Vondre Sweat | DT | TEN | 12 | 2 | 14 |
| 57 | Micah Robinson | CB | TEN | 6 | 8 |
| 58 | Kevin Winston Jr. | SAF | TEN | 8 | 1 | 19 |
| 59 | Marcus Harris | CB | TEN | 11 | 17 |
| 60 | Dorian Mausi | LB | TEN | 10 | 5 |
| 61 | Oluwafemi Oladejo | LB | TEN | 6 | 4 |
