| # | Player | Pos | Team | G | Pass yds | Pass TD | Rush yds | Rush TD | Rec | Rec yds | Rec TD | Sacks | Tackles | FP (PPR) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 17 | 1,202 | 10 | 102 | 924 | 7 | 3 | 416.6 | |||
| 2 | Brock Purdy | QB | SF | 9 | 2,167 | 20 |
| 147 |
| 3 |
| 177.4 |
| 3 | Jauan Jennings | WR | SF | 15 | 55 | 643 | 9 | 1 | 173.3 |
| 4 | George Kittle | TE | SF | 11 | -3 | 57 | 628 | 7 | 1 | 161.5 |
| 5 | Mac Jones | QB | SF | 11 | 2,151 | 13 | 60 | 1 | 130.0 |
| 6 | Jake Tonges | TE | SF | 10 | 34 | 293 | 5 | 5 | 93.3 |
| 7 | Kendrick Bourne | WR | SF | 14 | 37 | 551 | 92.1 |
| 8 | Ricky Pearsall | WR | SF | 9 | -2 | 36 | 528 | 1 | 88.6 |
| 9 | Brian Robinson | RB | SF | 17 | 400 | 2 | 8 | 25 | 62.5 |
| 10 | Demarcus Robinson | WR | SF | 14 | 6 | 22 | 276 | 1 | 58.2 |
| 11 | Kyle Juszczyk | FB | SF | 16 | -3 | 24 | 213 | 2 | 1 | 57.0 |
| 12 | Luke Farrell | TE | SF | 13 | 11 | 85 | 2 | 3 | 29.5 |
| 13 | Skyy Moore | WR | SF | 17 | 11 | 5 | 87 | 14.8 |
| 14 | Jordan Watkins | WR | SF | 2 | 2 | 26 | 4.6 |
| 15 | Connor Colby | G | SF | 4 | 1 | -1 | 0.9 |
| 16 | Thomas Morstead | P | SF | 15 |
| 17 | Jon Weeks | LS | SF | 2 | 1 |
| 18 | Trent Williams | OT | SF | 5 | 2 |
| 19 | Eric Kendricks | MLB | SF | 2 | 3 |
| 20 | Eli Apple | CB | SF | 1 | 1 |
| 21 | Jake Brendel | C | SF | 3 |
| 22 | Eddy Pineiro | K | SF | 14 |
| 23 | Siran Neal | CB | SF | 13 | 6 |
| 24 | Fred Warner | MLB | SF | 6 | 27 |
| 25 | Malik Turner | WR | SF | 2 | 3 |
| 26 | Kevin Givens | DT | SF | 2 | 1 |
| 27 | Matt Gay | K | SF | 12 |
| 28 | Luke Gifford | LB | SF | 14 | 12 |
| 29 | Clelin Ferrell | DE | SF | 8 | 4 | 13 |
| 30 | Nick Bosa | DE | SF | 3 | 2 | 9 |
| 31 | Bryce Huff | DE | SF | 14 | 4 | 13 |
| 32 | Colton McKivitz | OT | SF | 5 | 2 |
| 33 | Jordan Elliott | DT | SF | 14 | 8 |
| 34 | Yetur Gross-Matos | DE | SF | 6 | 3 |
| 35 | Jason Pinnock | SAF | SF | 13 | 27 |
| 36 | Deommodore Lenoir | CB | SF | 17 | 36 |
| 37 | Curtis Robinson | LB | SF | 10 | 18 |
| 38 | Garret Wallow | LB | SF | 6 | 2 |
| 39 | Chase Lucas | CB | SF | 10 | 6 |
| 40 | Sam Okuayinonu | DT | SF | 14 | 3 | 23 |
| 41 | Spencer Burford | OT | SF | 2 | 1 |
| 42 | Kalia Davis | DT | SF | 15 | 0.5 | 10 |
| 43 | Ji'Ayir Brown | SAF | SF | 16 | 43 |
| 44 | Darrell Luter Jr. | CB | SF | 9 | 16 |
| 45 | Robert Beal Jr. | DE | SF | 5 | 3 |
| 46 | Dee Winters | LB | SF | 17 | 64 |
| 47 | Brayden Willis | TE | SF | 6 | 3 |
| 48 | Jalen Graham | LB | SF | 1 |
| 49 | Keion White | DE | SF | 13 | 1.5 | 6 |
| 50 | Renardo Green | CB | SF | 14 | 36 |
| 51 | Dominick Puni | OT | SF | 4 | 1 |
| 52 | Malik Mustapha | SAF | SF | 12 | 42 |
| 53 | Isaac Guerendo | RB | SF | 7 | 2 |
| 54 | Tatum Bethune | LB | SF | 12 | 1 | 37 |
| 55 | Nick Martin | LB | SF | 4 | 8 |
| 56 | Upton Stout | CB | SF | 16 | 1 | 43 |
| 57 | Marques Sigle | SAF | SF | 13 | 28 |
| 58 | Mykel Williams | DE | SF | 9 | 1 | 10 |
| 59 | CJ West | DT | SF | 10 | 1 | 11 |
| 60 | Alfred Collins | DT | SF | 11 | 1 | 4 |
| 61 | Adrian Martinez | QB | SF | 1 | -1 | -0.1 |
