| # | Player | Pos | Team | G | Pass yds | Pass TD | Rush yds | Rush TD | Rec | Rec yds | Rec TD | Sacks | Tackles | FP (PPR) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jaxon Smith-Njigba | WR | SEA | 17 | 36 | 119 | 1,793 | 10 | 3 | 359.9 | ||||
| 2 | Sam Darnold | QB | SEA | 17 | 4,048 | 25 |
| 95 |
| 2 |
| 235.4 |
| 3 | Kenneth Walker III | RB | SEA | 17 | 1,027 | 5 | 31 | 282 | 1 | 191.9 |
| 4 | Zach Charbonnet | RB | SEA | 16 | 730 | 12 | 20 | 144 | 181.4 |
| 5 | Rashid Shaheed | WR | SEA | 18 | 69 | 59 | 687 | 2 | 1 | 156.6 |
| 6 | AJ Barner | TE | SEA | 17 | 14 | 1 | 52 | 519 | 6 | 1 | 147.3 |
| 7 | Cooper Kupp | WR | SEA | 16 | 47 | 593 | 2 | 1 | 116.3 |
| 8 | Tory Horton | WR | SEA | 8 | 13 | 161 | 5 | 65.1 |
| 9 | Elijah Arroyo | TE | SEA | 13 | 15 | 179 | 1 | 36.9 |
| 10 | George Holani | RB | SEA | 10 | 73 | 1 | 2 | 15 | 1 | 20.8 |
| 11 | Cody White | WR | SEA | 8 | 3 | 90 | 1 | 5 | 18.0 |
| 12 | Eric Saubert | TE | SEA | 9 | 4 | 31 | 5 | 9.1 |
| 13 | Cam Akers | RB | SEA | 4 | 32 | 1 | 19 | 7.2 |
| 14 | Dareke Young | WR | SEA | 8 | 2 | 48 | 7 | 6.8 |
| 15 | Jake Bobo | WR | SEA | 5 | 2 | 20 | 1 | 4.0 |
| 16 | Velus Jones Jr. | RB | SEA | 5 | 32 | 1 | 3.2 |
| 17 | Jacardia Wright | RB | SEA | 1 | 20 | 2.0 |
| 18 | Myles Gaskin | RB | SEA | 1 | 6 | 0.6 |
| 19 | Drew Lock | QB | SEA | 3 | 15 | -5 | 0.1 |
| 20 | DeMarcus Lawrence | LB | SEA | 16 | 6 | 23 |
| 21 | Jason Myers | K | SEA | 17 | 2 |
| 22 | Leonard Williams | DE | SEA | 16 | 7 | 32 |
| 23 | Jarran Reed | DT | SEA | 12 | 2.5 | 11 |
| 24 | Shaquill Griffin | CB | SEA | 1 | 7 |
| 25 | Michael Dickson | P | SEA | 16 |
| 26 | Uchenna Nwosu | LB | SEA | 15 | 7 | 15 |
| 27 | Julian Love | SAF | SEA | 7 | 1 | 22 |
| 28 | Ernest Jones | LB | SEA | 15 | 0.5 | 58 |
| 29 | Chazz Surratt | LB | SEA | 10 | 4 |
| 30 | Riq Woolen | CB | SEA | 15 | 32 |
| 31 | Josh Jobe | CB | SEA | 15 | 0.5 | 39 |
| 32 | D'Anthony Bell | SAF | SEA | 8 | 0.5 | 5 |
| 33 | Abraham Lucas | OT | SEA | 5 | 2 |
| 34 | Charles Cross | OT | SEA | 4 |
| 35 | Boye Mafe | LB | SEA | 16 | 2 | 11 |
| 36 | Coby Bryant | SAF | SEA | 15 | 37 |
| 37 | Brady Russell | FB | SEA | 10 | 8 |
| 38 | Mike Morris | DE | SEA | 11 | 11 |
| 39 | Olu Oluwatimi | C | SEA | 1 |
| 40 | Brandon Pili | DT | SEA | 7 | 1 |
| 41 | Patrick O'Connell | LB | SEA | 6 | 1 | 8 |
| 42 | Ty Okada | SAF | SEA | 15 | 1.5 | 45 |
| 43 | Chris Stoll | LS | SEA | 1 |
| 44 | Drake Thomas | LB | SEA | 16 | 3.5 | 45 |
| 45 | Anthony Bradford | G | SEA | 3 |
| 46 | Derick Hall | LB | SEA | 14 | 2 | 11 |
| 47 | Devon Witherspoon | CB | SEA | 12 | 0.5 | 48 |
| 48 | Byron Murphy II | DT | SEA | 16 | 7 | 21 |
| 49 | Nehemiah Pritchett | CB | SEA | 9 | 10 |
| 50 | Tyrice Knight | LB | SEA | 14 | 2 | 34 |
| 51 | Jalen Sundell | C | SEA | 3 |
| 52 | Jamie Sheriff | LB | SEA | 1 | 1 |
| 53 | Nick Kallerup | TE | SEA | 4 | 2 |
| 54 | Connor O'Toole | LB | SEA | 4 | 3 |
| 55 | Grey Zabel | G | SEA | 5 | 1 |
| 56 | Rylie Mills | DE | SEA | 2 | 1 |
| 57 | Robbie Ouzts | RB | SEA | 4 | 2 |
| 58 | Bryce Cabeldue | G | SEA | 1 |
| 59 | Nick Emmanwori | SAF | SEA | 14 | 2.5 | 55 |
| 60 | Jalen Milroe | QB | SEA | 3 | 4 | -1.6 |
