| # | Player | Pos | Team | G | Pass yds | Pass TD | Rush yds | Rush TD | Rec | Rec yds | Rec TD | Sacks | Tackles | FP (PPR) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Aaron Rodgers | QB | PIT | 16 | 3,322 | 24 | 61 | 1 | 1 | -9 | 227.1 | |||
| 2 | Kenneth Gainwell | RB | PIT | 17 |
| 537 |
| 5 |
| 73 |
| 486 |
| 3 |
| 3 |
| 221.3 |
| 3 | Jaylen Warren | RB | PIT | 16 | 958 | 6 | 40 | 333 | 2 | 217.1 |
| 4 | DK Metcalf | WR | PIT | 15 | 12 | 1 | 59 | 850 | 6 | 4 | 187.2 |
| 5 | Pat Freiermuth | TE | PIT | 15 | 41 | 486 | 4 | 113.6 |
| 6 | Calvin Austin III | WR | PIT | 14 | 31 | 372 | 3 | 86.2 |
| 7 | Jonnu Smith | TE | PIT | 17 | 70 | 1 | 38 | 222 | 2 | 85.2 |
| 8 | Darnell Washington | TE | PIT | 13 | 31 | 364 | 1 | 73.4 |
| 9 | Adam Thielen | WR | PIT | 14 | 19 | 186 | 39.6 |
| 10 | Roman Wilson | WR | PIT | 9 | 12 | 166 | 2 | 1 | 38.6 |
| 11 | Marquez Valdes-Scantling | WR | PIT | 9 | 14 | 120 | 1 | 32.0 |
| 12 | Connor Heyward | TE | PIT | 14 | 43 | 2 | 3 | 21 | 1 | 3 | 27.4 |
| 13 | Ben Skowronek | WR | PIT | 16 | 4 | 69 | 1 | 11 | 16.9 |
| 14 | Scott Miller | WR | PIT | 5 | 9 | 62 | 15.2 |
| 15 | Mason Rudolph | QB | PIT | 5 | 310 | 2 | 6 | 15.0 |
| 16 | Kaleb Johnson | RB | PIT | 10 | 69 | 1 | 9 | 8.8 |
| 17 | Spencer Anderson | G | PIT | 4 | 1 | 4 | 1 | 1.4 |
| 18 | Cameron Heyward | DT | PIT | 17 | 3.5 | 36 |
| 19 | Darius Slay | CB | PIT | 10 | 28 |
| 20 | Chris Boswell | K | PIT | 17 | 2 |
| 21 | Andrus Peat | G | PIT | 2 |
| 22 | Miles Killebrew | SAF | PIT | 4 | 3 |
| 23 | Jalen Ramsey | CB | PIT | 17 | 3 | 51 |
| 24 | Chuck Clark | DB | PIT | 13 | 29 |
| 25 | Jabrill Peppers | FS | PIT | 7 | 6 |
| 26 | T.J. Watt | OLB | PIT | 14 | 7 | 21 |
| 27 | Christian Kuntz | LS | PIT | 2 | 2 |
| 28 | Daniel Ekuale | DT | PIT | 4 | 4 |
| 29 | DeShon Elliott | SAF | PIT | 5 | 1 | 20 |
| 30 | Cole Holcomb | LB | PIT | 11 | 24 |
| 31 | Juan Thornhill | SAF | PIT | 8 | 23 |
| 32 | James Pierre | CB | PIT | 10 | 14 |
| 33 | Corliss Waitman | P | PIT | 17 |
| 34 | Kyle Dugger | SAF | PIT | 16 | 1 | 29 |
| 35 | Malik Harrison | LB | PIT | 10 | 24 |
| 36 | Patrick Queen | LB | PIT | 17 | 1 | 55 |
| 37 | Alex Highsmith | LB | PIT | 13 | 9.5 | 36 |
| 38 | Brandin Echols | CB | PIT | 14 | 1 | 34 |
| 39 | Asante Samuel Jr. | CB | PIT | 5 | 6 |
| 40 | Trey Sermon | RB | PIT | 3 |
| 41 | Jeremiah Moon | LB | PIT | 2 |
| 42 | Esezi Otomewo | DE | PIT | 6 | 1 | 5 |
| 43 | Dylan Cook | OT | PIT | 1 |
| 44 | DeMarvin Leal | DE | PIT | 1 | 1 |
| 45 | Lew Nichols III | RB | PIT | 1 |
| 46 | Nick Herbig | LB | PIT | 15 | 7.5 | 18 |
| 47 | D'Shawn Jamison | CB | PIT | 1 |
| 48 | Broderick Jones | OT | PIT | 2 |
| 49 | Keeanu Benton | DT | PIT | 17 | 5.5 | 25 |
| 50 | Joey Porter Jr. | CB | PIT | 14 | 1 | 34 |
| 51 | Mason McCormick | G | PIT | 1 |
| 52 | Logan Lee | DT | PIT | 4 | 2 |
| 53 | Payton Wilson | LB | PIT | 17 | 2 | 74 |
| 54 | Troy Fautanu | OT | PIT | 2 |
| 55 | Zach Frazier | C | PIT | 5 | 1 |
| 56 | Jack Sawyer | LB | PIT | 16 | 1 | 15 |
| 57 | Yahya Black | DE | PIT | 12 | 10 |
| 58 | Carson Bruener | LB | PIT | 12 | 7 |
| 59 | Sebastian Castro | SAF | PIT | 4 | 2 |
| 60 | Derrick Harmon | DT | PIT | 12 | 3 | 11 |
