| # | Player | Pos | Team | G | Pass yds | Pass TD | Rush yds | Rush TD | Rec | Rec yds | Rec TD | Sacks | Tackles | FP (PPR) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Ashton Jeanty | RB | LV | 17 | 975 | 5 | 55 | 346 | 5 | 1 | 245.1 | |||
| 2 | Brock Bowers | TE | LV | 12 | 2 |
| 64 |
| 680 |
| 7 |
| 2 |
| 176.2 |
| 3 | Geno Smith | QB | LV | 15 | 3,025 | 19 | 109 | 173.9 |
| 4 | Tre Tucker | WR | LV | 17 | 51 | 57 | 696 | 5 | 2 | 161.7 |
| 5 | Michael Mayer | TE | LV | 13 | 35 | 328 | 1 | 8 | 73.8 |
| 6 | Tyler Lockett | WR | LV | 17 | 32 | 291 | 1 | 67.1 |
| 7 | Jack Bech | WR | LV | 14 | 20 | 224 | 2 | 42.4 |
| 8 | Raheem Mostert | RB | LV | 12 | 104 | 12 | 70 | 29.4 |
| 9 | Ian Thomas | TE | LV | 9 | 13 | 114 | 24.4 |
| 10 | Dont'e Thornton Jr. | WR | LV | 11 | 10 | 135 | 1 | 23.5 |
| 11 | Shedrick Jackson | WR | LV | 3 | 3 | 4 | 56 | 1 | 1 | 15.9 |
| 12 | Zamir White | RB | LV | 5 | 32 | 4 | 24 | 9.6 |
| 13 | Albert Okwuegbunam | TE | LV | 1 | 5 | 36 | 8.6 |
| 14 | Kenny Pickett | QB | LV | 6 | 188 | 1 | 22 | 7.7 |
| 15 | Dylan Laube | RB | LV | 17 | 9 | 3 | 18 | 3 | 5.7 |
| 16 | Aidan O'Connell | QB | LV | 1 | 102 | 7 | 4.8 |
| 17 | Alex Bachman | WR | LV | 11 | 2 | 12 | 3.2 |
| 18 | Carter Runyon | TE | LV | 3 | 1 | 3 | 2 | 1.3 |
| 19 | Isaiah Pola-Mao | SAF | LV | 17 | 3 | 57 | 0.3 |
| 20 | Elandon Roberts | OLB | LV | 17 | 40 |
| 21 | Adam Butler | DT | LV | 15 | 1 | 19 |
| 22 | Jamal Adams | LB | LV | 17 | 1 | 28 |
| 23 | Daniel Carlson | K | LV | 17 | 1 |
| 24 | Alex Cappa | G | LV | 4 |
| 25 | Maxx Crosby | DE | LV | 15 | 10 | 42 |
| 26 | AJ Cole | P | LV | 17 | 1 |
| 27 | Lonnie Johnson | SAF | LV | 8 | 14 |
| 28 | Devin White | LB | LV | 17 | 2.5 | 90 |
| 29 | Jacob Bobenmoyer | LS | LV | 4 | 1 |
| 30 | Jeremy Chinn | SAF | LV | 15 | 1 | 64 |
| 31 | Darnay Holmes | CB | LV | 10 | 13 |
| 32 | DJ Turner | WR | LV | 1 |
| 33 | Jordan Meredith | C | LV | 3 |
| 34 | Jamin Davis | LB | LV | 1 | 1 |
| 35 | Stone Forsythe | OT | LV | 4 | 2 |
| 36 | Charles Snowden | DE | LV | 12 | 3 | 16 |
| 37 | Jon Rhattigan | LB | LV | 6 | 1 |
| 38 | Eric Stokes | CB | LV | 16 | 33 |
| 39 | Malcolm Koonce | DE | LV | 15 | 4.5 | 13 |
| 40 | Dylan Parham | G | LV | 4 |
| 41 | Thomas Booker | DT | LV | 17 | 16 |
| 42 | Tristin McCollum | SAF | LV | 9 | 11 |
| 43 | Kyu Blu Kelly | CB | LV | 12 | 31 |
| 44 | Tyree Wilson | DE | LV | 15 | 4 | 24 |
| 45 | Atonio Mafi | G | LV | 1 |
| 46 | Justin Shorter | TE | LV | 3 |
| 47 | Chris Smith II | S | LV | 3 | 1 |
| 48 | DJ Glaze | OT | LV | 3 |
| 49 | Decamerion Richardson | CB | LV | 10 | 9 |
| 50 | Tommy Eichenberg | LB | LV | 14 | 21 |
| 51 | Jonah Laulu | DT | LV | 17 | 4 | 21 |
| 52 | Will Putnam | C | LV | 1 |
| 53 | Chigozie Anusiem | DB | LV | 1 |
| 54 | Jackson Powers-Johnson | G | LV | 3 | 2 |
| 55 | Brennan Jackson | LB | LV | 2 | 2 |
| 56 | Caleb Rogers | G | LV | 1 |
| 57 | Tonka Hemingway | DT | LV | 7 | 4 | 8 |
| 58 | JJ Pegues | DT | LV | 7 | 3 |
| 59 | Cody Lindenberg | LB | LV | 6 | 4 |
| 60 | Greedy Vance | CB | LV | 4 | 7 |
| 61 | Jahfari Harvey | DE | LV | 1 |
| 62 | Darien Porter | CB | LV | 11 | 29 |
