| # | Player | Pos | Team | G | Pass yds | Pass TD | Rush yds | Rush TD | Rec | Rec yds | Rec TD | Sacks | Tackles | FP (PPR) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Puka Nacua | WR | LA | 16 | 105 | 1 | 129 | 1,715 | 10 | 375.0 | ||||
| 2 | Matthew Stafford | QB | LA | 17 | 4,707 | 46 | 1 |
| 1 |
| 350.4 |
| 3 | Kyren Williams | RB | LA | 17 | 1,252 | 10 | 36 | 281 | 3 | 263.3 |
| 4 | Davante Adams | WR | LA | 14 | 60 | 789 | 14 | 1 | 222.9 |
| 5 | Colby Parkinson | TE | LA | 14 | 43 | 408 | 8 | 1 | 129.8 |
| 6 | Blake Corum | RB | LA | 17 | 746 | 6 | 8 | 36 | 2 | 122.2 |
| 7 | Tyler Higbee | TE | LA | 10 | 25 | 281 | 3 | 71.1 |
| 8 | Davis Allen | TE | LA | 15 | 24 | 208 | 3 | 62.8 |
| 9 | Terrance Ferguson | TE | LA | 11 | 11 | 231 | 3 | 52.1 |
| 10 | Xavier Smith | WR | LA | 16 | 18 | 303 | 3 | 48.3 |
| 11 | Jordan Whittington | WR | LA | 15 | 12 | 18 | 171 | 2 | 36.3 |
| 12 | Tutu Atwell | WR | LA | 8 | 6 | 192 | 1 | 31.2 |
| 13 | Konata Mumpfield | WR | LA | 10 | 10 | 92 | 1 | 1 | 25.2 |
| 14 | Jared Verse | LB | LA | 17 | 7.5 | 31 | 6.0 |
| 15 | Ronnie Rivers | RB | LA | 6 | 46 | 2 | 4.6 |
| 16 | Jake McQuaide | LS | LA | 1 |
| 17 | D.J. Humphries | OT | LA | 1 |
| 18 | Rob Havenstein | OT | LA | 1 |
| 19 | Ahkello Witherspoon | CB | LA | 5 | 6 |
| 20 | Coleman Shelton | C | LA | 3 |
| 21 | Darious Williams | CB | LA | 11 | 17 |
| 22 | Poona Ford | DT | LA | 16 | 2 | 17 |
| 23 | Troy Reeder | LB | LA | 14 | 17 |
| 24 | Larrell Murchison | DE | LA | 7 | 2 | 2 |
| 25 | Kevin Dotson | G | LA | 2 |
| 26 | Kam Curl | SAF | LA | 17 | 2 | 75 |
| 27 | Alaric Jackson | OT | LA | 3 |
| 28 | Jack Heflin | DE | LA | 1 | 1 |
| 29 | Nate Landman | LB | LA | 17 | 2.5 | 62 |
| 30 | Cobie Durant | CB | LA | 17 | 29 |
| 31 | Quentin Lake | SAF | LA | 10 | 1 | 35 |
| 32 | Derion Kendrick | CB | LA | 7 | 5 |
| 33 | Roger McCreary | CB | LA | 10 | 1 | 23 |
| 34 | Alex Ward | LS | LA | 2 |
| 35 | Tanner Ingle | SAF | LA | 2 | 1 |
| 36 | Steve Avila | G | LA | 1 | 1 |
| 37 | Ethan Evans | P | LA | 17 | 1 |
| 38 | Desjuan Johnson | DE | LA | 5 | 2 | 4 |
| 39 | Nick Hampton | LB | LA | 5 | 4 |
| 40 | Byron Young | LB | LA | 17 | 12 | 44 |
| 41 | Kobie Turner | DE | LA | 17 | 7 | 23 |
| 42 | Emmanuel Forbes | CB | LA | 17 | 32 |
| 43 | Harrison Mevis | K | LA | 9 |
| 44 | Braden Fiske | DE | LA | 15 | 3 | 10 |
| 45 | Tyler Davis | DE | LA | 16 | 1 | 14 |
| 46 | Joshua Karty | K | LA | 8 | 1 |
| 47 | Beaux Limmer | G | LA | 1 |
| 48 | Josh Wallace | CB | LA | 9 | 18 |
| 49 | Omar Speights | LB | LA | 16 | 43 |
| 50 | Jaylen McCollough | SAF | LA | 17 | 2 | 35 |
| 51 | Justin Dedich | OL | LA | 1 |
| 52 | Kamren Kinchens | SAF | LA | 17 | 54 |
| 53 | Josaiah Stewart | LB | LA | 15 | 3 | 12 |
| 54 | Ty Hamilton | DT | LA | 9 | 1 |
| 55 | Shaun Dolac | LB | LA | 12 | 14 |
| 56 | Jimmy Garoppolo | QB | LA | 3 | -10 | -1.0 |
