| # | Player | Pos | Team | G | Pass yds | Pass TD | Rush yds | Rush TD | Rec | Rec yds | Rec TD | Sacks | Tackles | FP (PPR) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | RB | IND | 17 | 1,585 | 18 | 46 | 378 | 2 | 1 | 362.3 | |||
| 2 | Daniel Jones | QB | IND | 13 | 3,101 | 19 |
| 164 |
| 5 |
| 1 |
| 226.4 |
| 3 | Michael Pittman | WR | IND | 17 | 80 | 784 | 7 | 1 | 202.4 |
| 4 | Tyler Warren | TE | IND | 17 | 8 | 1 | 76 | 817 | 4 | 1 | 188.5 |
| 5 | Alec Pierce | WR | IND | 15 | 47 | 1,003 | 6 | 3 | 183.3 |
| 6 | Josh Downs | WR | IND | 16 | -2 | 58 | 566 | 4 | 2 | 138.4 |
| 7 | Ameer Abdullah | RB | IND | 13 | 60 | 1 | 16 | 99 | 5 | 37.9 |
| 8 | Philip Rivers | QB | IND | 3 | 544 | 4 | -1 | 31.7 |
| 9 | Riley Leonard | QB | IND | 5 | 415 | 2 | 27 | 2 | -3 | 31.0 |
| 10 | Mo Alie-Cox | TE | IND | 11 | 13 | 117 | 1 | 2 | 30.7 |
| 11 | Ashton Dulin | WR | IND | 12 | 44 | 5 | 106 | 6 | 20.0 |
| 12 | Andrew Ogletree | TE | IND | 11 | 4 | 27 | 1 | 5 | 12.7 |
| 13 | DJ Giddens | RB | IND | 5 | 96 | 9.6 |
| 14 | Tyler Goodson | RB | IND | 10 | 24 | 2 | 8 | 6 | 5.2 |
| 15 | Will Mallory | TE | IND | 1 | 1 | 16 | 2.6 |
| 16 | Anthony Gould | WR | IND | 11 | 2 | 6 | 2.6 |
| 17 | Anthony Richardson | QB | IND | 2 | 9 | -1 | 1 | 9 | 2.2 |
| 18 | Rigoberto Sanchez | P | IND | 15 | 16 | 0.6 |
| 19 | Rodney Thomas | SAF | IND | 11 | 3 | 13 | 0.3 |
| 20 | DeForest Buckner | DT | IND | 10 | 4 | 30 |
| 21 | Mike Hilton | CB | IND | 2 | 4 |
| 22 | Luke Rhodes | LS | IND | 2 | 1 |
| 23 | Laquon Treadwell | WR | IND | 6 | 6 |
| 24 | Xavien Howard | CB | IND | 4 | 7 |
| 25 | Kenny Moore II | CB | IND | 14 | 1.5 | 34 |
| 26 | Chris Wormley | NT | IND | 3 | 1 | 4 |
| 27 | Samson Ebukam | DE | IND | 14 | 2 | 21 |
| 28 | Grover Stewart | DT | IND | 17 | 0.5 | 21 |
| 29 | George Odum | DB | IND | 2 | 2 |
| 30 | Chris Lammons | DB | IND | 7 | 14 |
| 31 | Quenton Nelson | G | IND | 2 |
| 32 | Tyquan Lewis | DE | IND | 9 | 3 | 4 |
| 33 | Zaire Franklin | OLB | IND | 17 | 2 | 60 |
| 34 | Charvarius Ward | CB | IND | 7 | 17 |
| 35 | Braden Smith | OT | IND | 5 |
| 36 | Germaine Pratt | LB | IND | 16 | 65 |
| 37 | Danny Pinter | C | IND | 1 |
| 38 | Neville Gallimore | DT | IND | 15 | 3.5 | 18 |
| 39 | Kwity Paye | DE | IND | 16 | 4 | 14 |
| 40 | Camryn Bynum | SAF | IND | 17 | 1 | 47 |
| 41 | Cameron McGrone | LB | IND | 2 | 1 |
| 42 | Buddy Johnson | LB | IND | 7 | 8 |
| 43 | Sauce Gardner | CB | IND | 10 | 28 |
| 44 | Eric Johnson | DT | IND | 5 | 4 |
| 45 | Segun Olubi | LB | IND | 10 | 9 |
| 46 | Nick Cross | SAF | IND | 17 | 2.5 | 70 |
| 47 | Bernhard Raimann | OT | IND | 7 |
| 48 | Daniel Scott | SAF | IND | 2 | 2 |
| 49 | Jaylon Jones | CB | IND | 8 | 13 |
| 50 | Mekhi Blackmon | CB | IND | 17 | 1 | 50 |
| 51 | Cameron Mitchell | CB | IND | 7 | 13 |
| 52 | Blake Grupe | K | IND | 16 | 1 |
| 53 | Adetomiwa Adebawore | DT | IND | 14 | 4 | 13 |
| 54 | Austin Ajiake | LB | IND | 13 | 0.5 | 13 |
| 55 | Durell Nchami | DE | IND | 1 | 1 |
| 56 | Laiatu Latu | DE | IND | 16 | 8.5 | 25 |
| 57 | Jaylon Carlies | LB | IND | 1 |
| 58 | Spencer Shrader | K | IND | 5 |
| 59 | Dalton Tucker | G | IND | 2 |
| 60 | Matt Goncalves | OT | IND | 5 |
| 61 | Tanor Bortolini | C | IND | 5 | 1 |
| 62 | Jalen Travis | OT | IND | 2 |
| 63 | Johnathan Edwards | CB | IND | 9 | 19 |
| 64 | Coleman Owen | WR | IND | 2 |
| 65 | Trey Washington | SAF | IND | 2 |
| 66 | Ulysses Bentley IV | RB | IND | 1 |
| 67 | JT Tuimoloau | DE | IND | 11 | 6 |
