| # | Player | Pos | Team | G | Pass yds | Pass TD | Rush yds | Rush TD | Rec | Rec yds | Rec TD | Sacks | Tackles | FP (PPR) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Nico Collins | WR | HOU | 15 | 15 | 1 | 71 | 1,117 | 6 | 226.2 | ||||
| 2 | C.J. Stroud | QB | HOU | 14 | 3,041 | 19 |
| 209 |
| 1 |
| 208.5 |
| 3 | Dalton Schultz | TE | HOU | 17 | 82 | 777 | 3 | 1 | 177.7 |
| 4 | Woody Marks | RB | HOU | 16 | 703 | 2 | 24 | 208 | 3 | 145.1 |
| 5 | Jayden Higgins | WR | HOU | 17 | 41 | 525 | 6 | 1 | 129.5 |
| 6 | Xavier Hutchinson | WR | HOU | 16 | 22 | 35 | 428 | 3 | 2 | 98.0 |
| 7 | Nick Chubb | RB | HOU | 15 | 506 | 3 | 13 | 67 | 1 | 88.3 |
| 8 | Davis Mills | QB | HOU | 6 | 915 | 5 | 60 | 1 | 68.6 |
| 9 | Jaylin Noel | WR | HOU | 17 | 12 | 26 | 292 | 2 | 68.4 |
| 10 | Christian Kirk | WR | HOU | 11 | 28 | 239 | 1 | 2 | 57.9 |
| 11 | Jawhar Jordan | RB | HOU | 4 | 193 | 7 | 34 | 29.7 |
| 12 | Dare Ogunbowale | RB | HOU | 14 | 25 | 1 | 10 | 76 | 8 | 24.1 |
| 13 | Cade Stover | TE | HOU | 6 | 3 | 12 | 76 | 2 | 19.9 |
| 14 | Braxton Berrios | WR | HOU | 4 | 6 | 37 | 9.7 |
| 15 | British Brooks | RB | HOU | 8 | 78 | 6 | 7.8 |
| 16 | Justin Watson | WR | HOU | 3 | 3 | 30 | 6.0 |
| 17 | Jared Wayne | WR | HOU | 1 | 2 | 20 | 4.0 |
| 18 | Harrison Bryant | TE | HOU | 5 | 2 | 7 | 1 | 2.7 |
| 19 | Denico Autry | DT | HOU | 9 | 3.5 | 5 |
| 20 | Danielle Hunter | DE | HOU | 16 | 15 | 28 |
| 21 | Trent Brown | OT | HOU | 4 |
| 22 | Laken Tomlinson | G | HOU | 2 | 1 |
| 23 | Mario Edwards | DT | HOU | 9 | 1.5 | 6 |
| 24 | Ka'imi Fairbairn | K | HOU | 15 | 1 |
| 25 | Sheldon Rankins | DT | HOU | 15 | 3 | 14 |
| 26 | Derek Barnett | DE | HOU | 16 | 5 | 12 |
| 27 | Foley Fatukasi | DT | HOU | 4 | 1.5 | 5 |
| 28 | Tremon Smith | CB | HOU | 15 | 13 |
| 29 | M.J. Stewart | SAF | HOU | 7 | 15 |
| 30 | Tim Settle | DT | HOU | 10 | 1 | 6 |
| 31 | E.J. Speed | LB | HOU | 14 | 31 |
| 32 | Azeez Al-Shaair | LB | HOU | 16 | 48 |
| 33 | Matthew Wright | K | HOU | 4 |
| 34 | Tytus Howard | OT | HOU | 4 |
| 35 | Jakob Johnson | RB | HOU | 2 | 1 |
| 36 | Tommy Townsend | P | HOU | 17 |
| 37 | Myles Bryant | CB | HOU | 8 | 22 |
| 38 | Marlon Davidson | DE | HOU | 1 |
| 39 | Damon Arnette | CB | HOU | 2 | 3 |
| 40 | Leki Fotu | DT | HOU | 6 | 1 | 2 |
| 41 | K'Von Wallace | SAF | HOU | 2 | 6 |
| 42 | Darrell Taylor | DE | HOU | 3 | 1 |
| 43 | Naquan Jones | DT | HOU | 8 | 7 |
| 44 | Tommy Togiai | DT | HOU | 15 | 1.5 | 25 |
| 45 | Haggai Ndubuisi | DT | HOU | 1 |
| 46 | Derek Stingley Jr. | CB | HOU | 15 | 26 |
| 47 | Jalen Pitre | SAF | HOU | 14 | 41 |
| 48 | Damone Clark | LB | HOU | 9 | 14 |
| 49 | Jake Hansen | LB | HOU | 12 | 11 |
| 50 | Ja'Marcus Ingram | CB | HOU | 9 | 7 |
| 51 | Christian Harris | LB | HOU | 7 | 5 |
| 52 | Ed Ingram | G | HOU | 2 |
| 53 | Henry To'oTo'o | LB | HOU | 17 | 2.5 | 42 |
| 54 | Jarrett Patterson | C | HOU | 1 |
| 55 | Ameer Speed | DB | HOU | 2 | 1 |
| 56 | Kaevon Merriweather | SAF | HOU | 7 | 6 |
| 57 | Juice Scruggs | C | HOU | 3 |
| 58 | Dylan Horton | DE | HOU | 14 | 0.5 | 11 |
| 59 | Jake Andrews | C | HOU | 5 | 1 |
| 60 | Will Anderson Jr. | DE | HOU | 17 | 12 | 31 |
| 61 | Kamari Lassiter | CB | HOU | 16 | 57 |
| 62 | Jamal Hill | LB | HOU | 6 | 4 |
| 63 | Calen Bullock | SAF | HOU | 16 | 43 |
| 64 | Blake Fisher | OT | HOU | 4 |
| 65 | Jaylin Smith | CB | HOU | 3 | 3 |
| 66 | Jaylen Reed | SAF | HOU | 2 | 9 |
| 67 | Austin Brinkman | LS | HOU | 1 |
| 68 | Alijah Huzzie | CB | HOU | 1 | 3 |
| 69 | Aireontae Ersery | OT | HOU | 6 |
