| # | Player | Pos | Team | G | Pass yds | Pass TD | Rush yds | Rush TD | Rec | Rec yds | Rec TD | Sacks | Tackles | FP (PPR) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jahmyr Gibbs | RB | DET | 17 | 1,223 | 13 | 77 | 616 | 5 | 366.9 | ||||
| 2 | Amon-Ra St. Brown | WR | DET | 17 |
| 9 |
| 117 |
| 1,401 |
| 11 |
| 4 |
| 324.0 |
| 3 | Jared Goff | QB | DET | 17 | 4,564 | 34 | 45 | 297.1 |
| 4 | Jameson Williams | WR | DET | 17 | 12 | 65 | 1,117 | 7 | 1 | 219.9 |
| 5 | David Montgomery | RB | DET | 17 | 3 | 1 | 716 | 8 | 24 | 192 | 166.9 |
| 6 | Sam LaPorta | TE | DET | 9 | 40 | 489 | 3 | 1 | 106.9 |
| 7 | Isaac TeSlaa | WR | DET | 14 | 16 | 239 | 6 | 1 | 75.9 |
| 8 | Kalif Raymond | WR | DET | 15 | 19 | 24 | 289 | 1 | 66.8 |
| 9 | Brock Wright | TE | DET | 8 | 14 | 108 | 2 | 36.8 |
| 10 | Anthony Firkser | TE | DET | 5 | 8 | 53 | 13.3 |
| 11 | Tom Kennedy | WR | DET | 6 | 4 | 36 | 7.6 |
| 12 | Shane Zylstra | TE | DET | 1 | 3 | 20 | 1 | 5.0 |
| 13 | Ross Dwelley | TE | DET | 4 | 2 | 7 | 1 | 2.7 |
| 14 | Jacob Saylors | RB | DET | 11 | 11 | 4 | 1.1 |
| 15 | Craig Reynolds | RB | DET | 5 | 4 | 4 | 0.4 |
| 16 | Sione Vaki | RB | DET | 8 | 4 | 6 | 0.4 |
| 17 | Malik Cunningham | WR | DET | 1 | 1 | 0.1 |
| 18 | Chris Hubbard | OT | DET | 1 |
| 19 | Taylor Decker | OT | DET | 4 |
| 20 | Graham Glasgow | C | DET | 3 |
| 21 | DJ Reader | DE | DET | 13 | 11 |
| 22 | Jalen Mills | CB | DET | 4 | 3 |
| 23 | Arthur Maulet | CB | DET | 5 | 11 |
| 24 | Zach Cunningham | ILB | DET | 4 | 5 |
| 25 | Pat O'Connor | DE | DET | 7 | 5 |
| 26 | Dan Skipper | OT | DET | 1 |
| 27 | Alex Anzalone | MLB | DET | 16 | 2.5 | 52 |
| 28 | Al-Quadin Muhammad | DE | DET | 13 | 11 | 15 |
| 29 | Marcus Davenport | DE | DET | 6 | 1 | 5 |
| 30 | Avonte Maddox | CB | DET | 8 | 23 |
| 31 | D.J. Reed | CB | DET | 11 | 36 |
| 32 | Ty Summers | LB | DET | 1 |
| 33 | Jack Fox | P | DET | 16 | 2 |
| 34 | Anthony Pittman | LB | DET | 1 | 1 |
| 35 | Rock Ya-Sin | CB | DET | 15 | 26 |
| 36 | Giovanni Ricci | TE | DET | 2 |
| 37 | Khalil Dorsey | CB | DET | 7 | 6 |
| 38 | Daniel Thomas | SAF | DET | 9 | 10 |
| 39 | Amik Robertson | CB | DET | 17 | 42 |
| 40 | Roy Lopez | DT | DET | 14 | 2 | 11 |
| 41 | Alim McNeill | DT | DET | 8 | 1 | 5 |
| 42 | Grant Stuard | LB | DET | 14 | 5 |
| 43 | Penei Sewell | OT | DET | 2 |
| 44 | Derrick Barnes | LB | DET | 17 | 4 | 40 |
| 45 | Monty Rice | LB | DET | 1 |
| 46 | Aidan Hutchinson | DE | DET | 17 | 14.5 | 35 |
| 47 | Malcolm Rodriguez | LB | DET | 5 | 9 |
| 48 | Kerby Joseph | SAF | DET | 6 | 14 |
| 49 | Trevor Nowaske | LB | DET | 13 | 1 | 9 |
| 50 | Tyrus Wheat | DE | DET | 9 | 1.5 | 7 |
| 51 | Nick Whiteside | DB | DET | 3 | 3 |
| 52 | Tyler Lacy | DE | DET | 9 | 1 | 6 |
| 53 | Jack Campbell | LB | DET | 17 | 5 | 87 |
| 54 | Brian Branch | SAF | DET | 12 | 2.5 | 46 |
| 55 | Jake Bates | K | DET | 17 | 3 |
| 56 | Mekhi Wingo | DT | DET | 2 | 2 |
| 57 | Christian Mahogany | G | DET | 2 |
| 58 | Kingsley Eguakun | C | DET | 2 |
| 59 | Hogan Hatten | LS | DET | 2 |
| 60 | Loren Strickland | SAF | DET | 1 | 1 |
| 61 | Thomas Harper | SAF | DET | 10 | 26 |
| 62 | Terrion Arnold | CB | DET | 8 | 23 |
| 63 | Miles Frazier | G | DET | 1 |
| 64 | Dominic Lovett | WR | DET | 2 |
| 65 | Tyleik Williams | DT | DET | 13 | 1 | 8 |
| 66 | Tate Ratledge | G | DET | 5 |
| 67 | Kyle Allen | QB | DET | 2 | -3 | -0.3 |
