| # | Player | Pos | Team | G | Pass yds | Pass TD | Rush yds | Rush TD | Rec | Rec yds | Rec TD | Sacks | Tackles | FP (PPR) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Bo Nix | QB | DEN | 17 | 3,931 | 25 | 356 | 5 | 304.8 | |||||
| 2 | Courtland Sutton | WR | DEN | 17 |
| 74 |
| 1,017 |
| 7 |
| 2 |
| 219.7 |
| 3 | RJ Harvey | RB | DEN | 17 | 540 | 7 | 47 | 356 | 5 | 206.6 |
| 4 | Troy Franklin | WR | DEN | 17 | 12 | 65 | 709 | 6 | 2 | 177.1 |
| 5 | J.K. Dobbins | RB | DEN | 10 | 772 | 4 | 11 | 37 | 115.9 |
| 6 | Evan Engram | TE | DEN | 16 | 7 | 50 | 461 | 1 | 102.8 |
| 7 | Marvin Mims Jr. | WR | DEN | 15 | 78 | 1 | 37 | 322 | 1 | 95.0 |
| 8 | Pat Bryant | WR | DEN | 13 | 31 | 378 | 1 | 3 | 74.8 |
| 9 | Adam Trautman | TE | DEN | 13 | 20 | 195 | 1 | 45.5 |
| 10 | Tyler Badie | RB | DEN | 16 | 23 | 19 | 141 | 3 | 35.4 |
| 11 | Lil'Jordan Humphrey | WR | DEN | 7 | 13 | 156 | 1 | 34.6 |
| 12 | Jaleel McLaughlin | RB | DEN | 8 | 187 | 1 | 4 | 27 | 31.4 |
| 13 | Nate Adkins | TE | DEN | 6 | 6 | 48 | 1 | 1 | 16.8 |
| 14 | Adam Prentice | RB | DEN | 13 | 44 | 6 | 53 | 3 | 15.7 |
| 15 | Michael Bandy | WR | DEN | 4 | 4 | 50 | 1 | 15.0 |
| 16 | Lucas Krull | TE | DEN | 2 | 2 | 15 | 3.5 |
| 17 | Marcedes Lewis | TE | DEN | 1 |
| 18 | Alex Singleton | LB | DEN | 16 | 1 | 52 |
| 19 | Wil Lutz | K | DEN | 17 |
| 20 | D.J. Jones | DT | DEN | 16 | 3 | 20 |
| 21 | Garett Bolles | OT | DEN | 5 |
| 22 | John Franklin-Myers | DE | DEN | 13 | 7.5 | 12 |
| 23 | Mike McGlinchey | OT | DEN | 7 | 1 |
| 24 | Ben Powers | G | DEN | 3 |
| 25 | Dre Greenlaw | LB | DEN | 8 | 1 | 15 |
| 26 | P.J. Locke | SAF | DEN | 8 | 9 |
| 27 | Zach Allen | DE | DEN | 17 | 7 | 13 |
| 28 | Malcolm Roach | DT | DEN | 12 | 4 | 14 |
| 29 | Brandon Jones | SAF | DEN | 14 | 0.5 | 42 |
| 30 | Matt Peart | OT | DEN | 1 |
| 31 | Justin Strnad | LB | DEN | 13 | 4.5 | 21 |
| 32 | Talanoa Hufanga | SAF | DEN | 17 | 2 | 67 |
| 33 | Devon Key | SAF | DEN | 15 | 19 |
| 34 | Pat Surtain II | CB | DEN | 14 | 37 |
| 35 | Mitchell Fraboni | LS | DEN | 5 | 3 |
| 36 | Jonathon Cooper | LB | DEN | 17 | 8 | 21 |
| 37 | Quinn Meinerz | G | DEN | 2 |
| 38 | Nik Bonitto | LB | DEN | 17 | 14 | 30 |
| 39 | Delarrin Turner-Yell | SAF | DEN | 1 |
| 40 | Luke Wattenberg | C | DEN | 3 |
| 41 | Jordan Jackson | DT | DEN | 4 | 3 |
| 42 | Ja'Quan McMillian | CB | DEN | 16 | 4 | 40 |
| 43 | Dondrea Tillman | LB | DEN | 17 | 4 | 13 |
| 44 | Eyioma Uwazurike | DT | DEN | 16 | 3.5 | 15 |
| 45 | Reese Taylor | CB | DEN | 2 | 2 |
| 46 | Riley Moss | CB | DEN | 17 | 1 | 57 |
| 47 | JL Skinner | SAF | DEN | 12 | 8 |
| 48 | Alex Palczewski | OT | DEN | 2 |
| 49 | Kris Abrams-Draine | CB | DEN | 11 | 21 |
| 50 | Frank Crum | OT | DEN | 1 |
| 51 | Jonah Elliss | LB | DEN | 11 | 2.5 | 14 |
| 52 | Sai'vion Jones | DE | DEN | 1 |
| 53 | Que Robinson | LB | DEN | 6 | 0.5 | 5 |
| 54 | Jeremy Crawshaw | P | DEN | 17 |
| 55 | Karene Reid | LB | DEN | 4 | 4 |
| 56 | Jordan Turner | LB | DEN | 4 | 1 |
| 57 | Jahdae Barron | CB | DEN | 16 | 24 |
| 58 | Jarrett Stidham | QB | DEN | 1 | -1 | -0.1 |
