| # | Player | Pos | Team | G | Pass yds | Pass TD | Rush yds | Rush TD | Rec | Rec yds | Rec TD | Sacks | Tackles | FP (PPR) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Harold Fannin Jr. | TE | CLE | 16 | 13 | 1 | 72 | 731 | 6 | 186.4 | ||||
| 2 | Quinshon Judkins | RB | CLE | 14 |
| 827 |
| 7 |
| 26 |
| 171 |
| 169.8 |
| 3 | Jerry Jeudy | WR | CLE | 17 | 5 | 50 | 602 | 2 | 3 | 120.7 |
| 4 | Dylan Sampson | RB | CLE | 15 | 175 | 33 | 271 | 2 | 1 | 87.6 |
| 5 | David Njoku | TE | CLE | 11 | 33 | 293 | 4 | 86.3 |
| 6 | Shedeur Sanders | QB | CLE | 8 | 1,400 | 7 | 169 | 1 | 84.9 |
| 7 | Dillon Gabriel | QB | CLE | 10 | 937 | 7 | 86 | 70.1 |
| 8 | Cedric Tillman | WR | CLE | 12 | 21 | 270 | 2 | 1 | 60.0 |
| 9 | Isaiah Bond | WR | CLE | 15 | 29 | 18 | 338 | 1 | 54.7 |
| 10 | Jerome Ford | RB | CLE | 13 | 73 | 26 | 103 | 1 | 43.6 |
| 11 | Malachi Corley | WR | CLE | 12 | 127 | 11 | 79 | 1 | 31.6 |
| 12 | Jamari Thrash | WR | CLE | 8 | 10 | 107 | 20.7 |
| 13 | Raheim Sanders | RB | CLE | 4 | 92 | 1 | 3 | 21 | 20.3 |
| 14 | Trayveon Williams | RB | CLE | 6 | 36 | 8 | 55 | 17.1 |
| 15 | Gage Larvadain | WR | CLE | 13 | 3 | 7 | 71 | 14.4 |
| 16 | Brenden Bates | TE | CLE | 5 | 4 | 48 | 1 | 8.8 |
| 17 | Sal Cannella | TE | CLE | 2 | 2 | 11 | 3.1 |
| 18 | Blake Whiteheart | TE | CLE | 9 | 2 | 4 | 4 | 2.4 |
| 19 | Cornelius Lucas | OT | CLE | 2 |
| 20 | Shelby Harris | DT | CLE | 17 | 1 | 12 |
| 21 | Joel Bitonio | G | CLE | 2 | 1 |
| 22 | DeAndre Carter | WR | CLE | 4 |
| 23 | Jack Conklin | OT | CLE | 3 |
| 24 | Maliek Collins | DT | CLE | 11 | 6.5 | 14 |
| 25 | Myles Garrett | DE | CLE | 17 | 23 | 40 |
| 26 | Cam Robinson | OT | CLE | 7 |
| 27 | Ethan Pocic | C | CLE | 2 |
| 28 | Rayshawn Jenkins | SAF | CLE | 16 | 19 |
| 29 | Wyatt Teller | G | CLE | 4 |
| 30 | Corey Bojorquez | P | CLE | 17 |
| 31 | Maurice Hurst | DT | CLE | 2 |
| 32 | Jerome Baker | OLB | CLE | 16 | 1.5 | 10 |
| 33 | Denzel Ward | CB | CLE | 14 | 27 |
| 34 | D'Angelo Ross | CB | CLE | 3 | 5 |
| 35 | Devin Bush | LB | CLE | 17 | 2 | 61 |
| 36 | Grant Delpit | SAF | CLE | 17 | 3 | 45 |
| 37 | Rex Sunahara | LS | CLE | 6 | 3 |
| 38 | Sam Kamara | LB | CLE | 3 | 1 |
| 39 | Teven Jenkins | G | CLE | 1 | 1 |
| 40 | Tyson Campbell | CB | CLE | 17 | 54 |
| 41 | Alex Wright | DE | CLE | 13 | 5.5 | 18 |
| 42 | Kaden Davis | WR | CLE | 1 |
| 43 | Sam Webb | CB | CLE | 3 | 3 |
| 44 | Tre Avery | CB | CLE | 8 | 6 |
| 45 | Cameron Thomas | DE | CLE | 12 | 2.5 | 7 |
| 46 | Andre Szmyt | K | CLE | 17 | 1 |
| 47 | Isaiah McGuire | DE | CLE | 15 | 2 | 13 |
| 48 | Luke Wypler | C | CLE | 5 | 1 |
| 49 | Mohamoud Diabate | LB | CLE | 15 | 22 |
| 50 | Ronnie Hickman Jr. | SAF | CLE | 17 | 51 |
| 51 | Dawand Jones | OT | CLE | 2 |
| 52 | Myles Harden | CB | CLE | 16 | 25 |
| 53 | Chris Edmonds | SAF | CLE | 5 | 1 |
| 54 | KT Leveston | OT | CLE | 6 | 1 |
| 55 | Mike Hall Jr. | DT | CLE | 7 | 1.5 | 4 |
| 56 | Adin Huntington | DE | CLE | 9 | 0.5 | 7 |
| 57 | Dom Jones | CB | CLE | 2 | 4 |
| 58 | Easton Mascarenas-Arnold | LB | CLE | 7 | 4 |
| 59 | Donovan McMillon | SAF | CLE | 12 | 1 | 6 |
| 60 | Carson Schwesinger | LB | CLE | 16 | 2.5 | 58 |
| 61 | Mason Graham | DT | CLE | 17 | 0.5 | 26 |
