| # | Player | Pos | Team | G | Pass yds | Pass TD | Rush yds | Rush TD | Rec | Rec yds | Rec TD | Sacks | Tackles | FP (PPR) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Caleb Williams | QB | CHI | 17 | 3,942 | 27 | 383 | 3 | 2 | 22 | 1 | 1 | 318.2 | |
| 2 | D'Andre Swift | RB | CHI | 16 |
| 1,087 |
| 9 |
| 34 |
| 299 |
| 1 |
| 228.6 |
| 3 | DJ Moore | WR | CHI | 17 | 2 | 1 | 79 | 1 | 50 | 682 | 6 | 1 | 172.2 |
| 4 | Colston Loveland | TE | CHI | 16 | -2 | 58 | 713 | 6 | 1 | 165.1 |
| 5 | Kyle Monangai | RB | CHI | 17 | 783 | 5 | 18 | 164 | 146.7 |
| 6 | Rome Odunze | WR | CHI | 12 | 44 | 661 | 6 | 146.1 |
| 7 | Luther Burden III | WR | CHI | 15 | 37 | 47 | 652 | 2 | 127.9 |
| 8 | Olamide Zaccheaus | WR | CHI | 14 | 25 | 39 | 313 | 2 | 84.8 |
| 9 | Cole Kmet | TE | CHI | 16 | 30 | 347 | 2 | 78.7 |
| 10 | Jahdae Walker | WR | CHI | 6 | 6 | 87 | 2 | 26.7 |
| 11 | Brittain Brown | RB | CHI | 2 | 37 | 1 | 9.7 |
| 12 | Durham Smythe | TE | CHI | 7 | 4 | 25 | 1 | 6.5 |
| 13 | Devin Duvernay | WR | CHI | 17 | 2 | 26 | 1 | 4.6 |
| 14 | Tyson Bagent | QB | CHI | 2 | 47 | 7 | 2.6 |
| 15 | Roschon Johnson | RB | CHI | 6 | 17 | 6 | 1.7 |
| 16 | Cairo Santos | K | CHI | 15 |
| 17 | Grady Jarrett | DT | CHI | 13 | 1.5 | 14 |
| 18 | Joe Thuney | G | CHI | 2 |
| 19 | Andrew Billings | DT | CHI | 15 | 1 | 16 |
| 20 | Kevin Byard | FS | CHI | 17 | 58 |
| 21 | Jalen Reeves-Maybin | LB | CHI | 1 | 2 |
| 22 | Tanoh Kpassagnon | DE | CHI | 4 | 1 | 4 |
| 23 | Scott Daly | LS | CHI | 3 |
| 24 | Jonathan Owens | DB | CHI | 13 | 9 |
| 25 | Tremaine Edmunds | MLB | CHI | 13 | 1 | 57 |
| 26 | C.J. Gardner-Johnson | SAF | CHI | 13 | 3 | 45 |
| 27 | T.J. Edwards | LB | CHI | 10 | 0.5 | 33 |
| 28 | Montez Sweat | DE | CHI | 17 | 10 | 31 |
| 29 | Chris Williams | DL | CHI | 10 | 1 | 6 |
| 30 | Jonah Jackson | G | CHI | 4 | 1 |
| 31 | Jaylon Johnson | CB | CHI | 7 | 14 |
| 32 | Dayo Odeyingbo | DE | CHI | 8 | 1 | 9 |
| 33 | Nick McCloud | CB | CHI | 10 | 18 |
| 34 | Amen Ogbongbemiga | LB | CHI | 3 | 5 |
| 35 | Drew Dalman | C | CHI | 3 |
| 36 | Joe Tryon-Shoyinka | DE | CHI | 10 | 10 |
| 37 | Nahshon Wright | CB | CHI | 17 | 50 |
| 38 | Nikola Kalinic | TE | CHI | 2 | 1 |
| 39 | Braxton Jones | OT | CHI | 1 |
| 40 | Dominique Robinson | DE | CHI | 10 | 1.5 | 11 |
| 41 | Elijah Hicks | SAF | CHI | 13 | 9 |
| 42 | Jaylon Jones | DB | CHI | 11 | 9 |
| 43 | Josh Blackwell | CB | CHI | 13 | 3 |
| 44 | D'Marco Jackson | LB | CHI | 13 | 1 | 18 |
| 45 | Dallis Flowers | CB | CHI | 1 | 1 |
| 46 | Daniel Hardy | DE | CHI | 13 | 7 |
| 47 | Kyler Gordon | CB | CHI | 3 | 1 | 5 |
| 48 | Jaquan Brisker | SAF | CHI | 17 | 1 | 50 |
| 49 | Noah Sewell | LB | CHI | 13 | 32 |
| 50 | Darnell Wright | OT | CHI | 9 |
| 51 | Gervon Dexter Sr. | DT | CHI | 16 | 6 | 20 |
| 52 | Tyrique Stevenson | CB | CHI | 12 | 35 |
| 53 | Theo Benedet | OT | CHI | 5 |
| 54 | Tory Taylor | P | CHI | 17 | 1 |
| 55 | Austin Booker | DE | CHI | 10 | 4.5 | 19 |
| 56 | Ruben Hyppolite II | LB | CHI | 3 | 3 |
| 57 | Ozzy Trapilo | OT | CHI | 2 |
| 58 | Shemar Turner | DT | CHI | 2 | 5 |
| 59 | Travis Homer | RB | CHI | 8 | -2 | 5 | -0.2 |
