| # | Player | Pos | Team | G | Pass yds | Pass TD | Rush yds | Rush TD | Rec | Rec yds | Rec TD | Sacks | Tackles | FP (PPR) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Josh Allen | QB | BUF | 16 | 3,668 | 25 | 579 | 14 | 364.6 | |||||
| 2 | James Cook | RB | BUF | 17 | 1,621 |
| 12 |
| 33 |
| 291 |
| 2 |
| 302.2 |
| 3 | Khalil Shakir | WR | BUF | 16 | 5 | 72 | 719 | 4 | 2 | 166.4 |
| 4 | Dalton Kincaid | TE | BUF | 12 | 39 | 571 | 5 | 126.1 |
| 5 | Dawson Knox | TE | BUF | 16 | 36 | 417 | 4 | 1 | 103.7 |
| 6 | Keon Coleman | WR | BUF | 12 | 38 | 404 | 4 | 1 | 102.4 |
| 7 | Ty Johnson | RB | BUF | 17 | 200 | 3 | 24 | 263 | 2 | 1 | 100.3 |
| 8 | Ray Davis | RB | BUF | 17 | 275 | 10 | 86 | 2 | 64.1 |
| 9 | Jackson Hawes | TE | BUF | 13 | 16 | 187 | 3 | 52.7 |
| 10 | Josh Palmer | WR | BUF | 12 | 22 | 303 | 1 | 52.3 |
| 11 | Brandin Cooks | WR | BUF | 13 | 24 | 279 | 51.9 |
| 12 | Tyrell Shavers | WR | BUF | 11 | 15 | 245 | 1 | 1 | 45.5 |
| 13 | Mitchell Trubisky | QB | BUF | 4 | 313 | 4 | 6 | 31.1 |
| 14 | Gabe Davis | WR | BUF | 6 | 12 | 129 | 1 | 1 | 30.9 |
| 15 | Elijah Moore | WR | BUF | 9 | 24 | 1 | 9 | 112 | 28.6 |
| 16 | Curtis Samuel | WR | BUF | 6 | 7 | 81 | 1 | 1 | 21.1 |
| 17 | Keleki Latu | TE | BUF | 3 | 4 | 35 | 1 | 7.5 |
| 18 | Reggie Gilliam | FB | BUF | 11 | 4 | 2 | 24 | 6 | 4.8 |
| 19 | Matt Prater | K | BUF | 15 |
| 20 | Jordan Poyer | FS | BUF | 10 | 0.5 | 31 |
| 21 | DaQuan Jones | DT | BUF | 12 | 3 | 10 |
| 22 | Shaq Thompson | OLB | BUF | 12 | 1 | 33 |
| 23 | Jordan Phillips | DT | BUF | 8 | 1 | 5 |
| 24 | Reid Ferguson | LS | BUF | 1 |
| 25 | Joey Bosa | DE | BUF | 15 | 5 | 17 |
| 26 | Matt Milano | OLB | BUF | 12 | 3.5 | 34 |
| 27 | Tre'Davious White | CB | BUF | 16 | 28 |
| 28 | Dion Dawkins | OT | BUF | 8 |
| 29 | Larry Ogunjobi | DT | BUF | 8 | 10 |
| 30 | Mike Badgley | K | BUF | 9 |
| 31 | Taron Johnson | CB | BUF | 13 | 34 |
| 32 | Mitch Wishnowsky | P | BUF | 12 | 1 |
| 33 | Darnell Savage | SAF | BUF | 9 | 10 |
| 34 | Mecole Hardman | WR | BUF | 2 |
| 35 | Ed Oliver | DT | BUF | 3 | 3 | 9 |
| 36 | Cam Lewis | CB | BUF | 16 | 33 |
| 37 | Taylor Rapp | SAF | BUF | 6 | 17 |
| 38 | David Edwards | G | BUF | 2 |
| 39 | Connor McGovern | C | BUF | 2 |
| 40 | Michael Hoecht | LB | BUF | 2 | 2 | 2 |
| 41 | Sam Franklin Jr. | SAF | BUF | 12 | 10 |
| 42 | Dane Jackson | CB | BUF | 1 |
| 43 | A.J. Epenesa | DE | BUF | 15 | 2.5 | 17 |
| 44 | Damar Hamlin | SAF | BUF | 1 | 1 |
| 45 | Greg Rousseau | DE | BUF | 16 | 7 | 23 |
| 46 | Spencer Brown | OT | BUF | 4 |
| 47 | Terrel Bernard | LB | BUF | 12 | 39 |
| 48 | Christian Benford | CB | BUF | 14 | 2 | 31 |
| 49 | Baylon Spector | LB | BUF | 3 | 2 |
| 50 | Ryan Van Demark | OT | BUF | 1 |
| 51 | Alec Anderson | OT | BUF | 2 |
| 52 | Phidarian Mathis | DT | BUF | 5 | 4 |
| 53 | O'Cyrus Torrence | G | BUF | 1 |
| 54 | Dorian Williams | LB | BUF | 16 | 28 |
| 55 | Brad Robbins | P | BUF | 1 |
| 56 | Andre Jones Jr. | DE | BUF | 2 | 1 |
| 57 | Brandon Codrington | CB | BUF | 4 |
| 58 | Zion Logue | DT | BUF | 2 | 0.5 | 1 |
| 59 | Joe Andreessen | LB | BUF | 14 | 12 |
| 60 | Cole Bishop | SAF | BUF | 16 | 2 | 52 |
| 61 | Sedrick Van Pran-Granger | C | BUF | 1 |
| 62 | Javon Solomon | DE | BUF | 12 | 1 | 11 |
| 63 | Jordan Hancock | CB | BUF | 9 | 9 |
| 64 | Dorian Strong | CB | BUF | 4 | 9 |
| 65 | Keonta Jenkins | LB | BUF | 3 | 5 |
| 66 | Maxwell Hairston | CB | BUF | 8 | 14 |
| 67 | Deone Walker | DT | BUF | 15 | 1 | 15 |
| 68 | T.J. Sanders | DT | BUF | 10 | 1 | 7 |
