| # | Player | Pos | Team | G | Pass yds | Pass TD | Rush yds | Rush TD | Rec | Rec yds | Rec TD | Sacks | Tackles | FP (PPR) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 17 | 1,202 | 10 | 102 | 924 | 7 | 3 | 416.6 | |||
| 2 | Brian Robinson | RB | SF | 17 | 400 | 2 | 8 | 25 | 62.5 | |||||
| 3 | Kyle Juszczyk | FB | SF | 16 | -3 | 24 | 213 | 2 | 1 | 57.0 | ||||
| 4 | Isaac Guerendo | RB | SF | 7 | 2 |
