| # | Player | Pos | Team | G | Pass yds | Pass TD | Rush yds | Rush TD | Rec | Rec yds | Rec TD | Sacks | Tackles | FP (PPR) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Kevin Givens | DT | SF | 2 | 1 | |||||||||
| 2 | Clelin Ferrell | DE | SF | 8 | 4 | 13 | ||||||||
| 3 | Nick Bosa | DE | SF | 3 | 2 | 9 | ||||||||
| 4 | Bryce Huff | DE | SF | 14 | 4 | 13 | ||||||||
| 5 | Jordan Elliott | DT | SF | 14 | 8 | |||||||||
| 6 | Yetur Gross-Matos | DE | SF | 6 | 3 | |||||||||
| 7 | Sam Okuayinonu | DT | SF | 14 | 3 | 23 | ||||||||
| 8 | Kalia Davis | DT | SF | 15 | 0.5 | 10 | ||||||||
| 9 | Robert Beal Jr. | DE | SF | 5 | 3 | |||||||||
| 10 | Keion White | DE | SF | 13 | 1.5 | 6 | ||||||||
| 11 | Mykel Williams | DE | SF | 9 | 1 | 10 | ||||||||
| 12 | CJ West | DT | SF | 10 | 1 | 11 | ||||||||
| 13 | Alfred Collins | DT | SF | 11 | 1 | 4 |
