| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | vs | NYG | 21-6 | W | 6 | 45.5 | FedExField |
| 2025-09-11 | 2 | @ | GB | 18-27 | L | 3.5 | 48.5 | Lambeau Field |
| 2025-09-21 | 3 | vs | LV | 41-24 | W | 2.5 | 43.5 | FedExField |
| 2025-09-28 | 4 | @ | ATL | 27-34 | L | 2.5 | 43.5 | Mercedes-Benz Stadium |
| 2025-10-05 | 5 | @ | LAC | 27-10 | W | 2.5 | 47.5 | SoFi Stadium |
| 2025-10-13 | 6 | vs | CHI | 24-25 | L | 5.5 | 49.5 | FedExField |
| 2025-10-19 | 7 | @ | DAL | 22-44 | L | 1.5 | 54.5 | AT&T Stadium |
| 2025-10-27 | 8 | @ | KC | 7-28 | L | 10.5 | 48.5 | GEHA Field at Arrowhead Stadium |
| 2025-11-02 | 9 | vs | SEA | 14-38 | L | -2.5 | 47.5 | FedExField |
| 2025-11-09 | 10 | vs | DET | 22-44 | L | -8.5 | 49.5 | FedExField |
| 2025-11-16 | 11 | @ | MIA | 13-16 | L | 2.5 | 47.5 | Hard Rock Stadium |
| 2025-11-30 | 13 | vs | DEN | 26-27 | L | -6.5 | 43.5 | FedExField |
| 2025-12-07 | 14 | @ | MIN | 0-31 | L | -1.5 | 43.5 | U.S. Bank Stadium |
| 2025-12-14 | 15 | @ | NYG | 29-21 | W | 2.5 | 46.5 | MetLife Stadium |
| 2025-12-20 | 16 | vs | PHI | 18-29 | L | -7 | 43.5 | FedExField |
| 2025-12-25 | 17 | vs | DAL | 23-30 | L | -8.5 | 50.5 | FedExField |
| 2026-01-04 | 18 | @ | PHI | 24-17 | W | 3 | 38.5 | Lincoln Financial Field |
