| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | vs | SF | 13-17 | L | -2.5 | 43.5 | Lumen Field |
| 2025-09-14 | 2 | @ | PIT | 31-17 | W | 3.5 | 40.5 | Acrisure Stadium |
| 2025-09-21 | 3 | vs | NO | 44-13 | W | 7.5 | 41.5 | Lumen Field |
| 2025-09-25 | 4 | @ | ARI | 23-20 | W | -1.5 | 43.5 | State Farm Stadium |
| 2025-10-05 | 5 | vs | TB | 35-38 | L | 3.5 | 44.5 | Lumen Field |
| 2025-10-12 | 6 | @ | JAX | 20-12 | W | -1.5 | 47.5 | TIAA Bank Stadium |
| 2025-10-20 | 7 | vs | HOU | 27-19 | W | 3 | 41.5 | Lumen Field |
| 2025-11-02 | 9 | @ | WAS | 38-14 | W | -2.5 | 47.5 | FedExField |
| 2025-11-09 | 10 | vs | ARI | 44-22 | W | 7 | 44.5 | Lumen Field |
| 2025-11-16 | 11 | @ | LA | 19-21 | L | 3 | 49.5 | SoFi Stadium |
| 2025-11-23 | 12 | @ | TEN | 30-24 | W | -12.5 | 41.5 | Nissan Stadium |
| 2025-11-30 | 13 | vs | MIN | 26-0 | W | 12.5 | 42.5 | Lumen Field |
| 2025-12-07 | 14 | @ | ATL | 37-9 | W | -7 | 44.5 | Mercedes-Benz Stadium |
| 2025-12-14 | 15 | vs | IND | 18-16 | W | 13.5 | 41.5 | Lumen Field |
| 2025-12-18 | 16 | vs | LA | 38-37 | W | 1.5 | 42.5 | Lumen Field |
| 2025-12-28 | 17 | @ | CAR | 27-10 | W | -6.5 | 42.5 | Bank of America Stadium |
| 2026-01-03 | 18 | @ | SF | 13-3 | W | -2.5 | 47.5 | Levi's Stadium |
| 2026-01-17 | 20 | vs | SF | 41-6 | W | 6.5 | 44.5 | Lumen Field |
| 2026-01-25 | 21 | vs | LA | 31-27 | W | 2.5 | 45.5 | Lumen Field |
| 2026-02-08 | 22 | @ | NE | 29-13 | W | -4.5 | 45.5 | Levi's Stadium |
