| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-04 | 1 | vs | DAL | 24-20 | W | 8.5 | 47.5 | Lincoln Financial Field |
| 2025-09-14 | 2 | @ | KC | 20-17 | W | -1.5 | 46.5 | GEHA Field at Arrowhead Stadium |
| 2025-09-21 | 3 | vs | LA | 33-26 | W | 3.5 | 45.5 | Lincoln Financial Field |
| 2025-09-28 | 4 | @ | TB | 31-25 | W | -3.5 | 44.5 | Raymond James Stadium |
| 2025-10-05 | 5 | vs | DEN | 17-21 | L | 3.5 | 44.5 | Lincoln Financial Field |
| 2025-10-09 | 6 | @ | NYG | 17-34 | L | -7 | 40.5 | MetLife Stadium |
| 2025-10-19 | 7 | @ | MIN | 28-22 | W | -2.5 | 43.5 | U.S. Bank Stadium |
| 2025-10-26 | 8 | vs | NYG | 38-20 | W | 7 | 43.5 | Lincoln Financial Field |
| 2025-11-10 | 10 | @ | GB | 10-7 | W | 1.5 | 45.5 | Lambeau Field |
| 2025-11-16 | 11 | vs | DET | 16-9 | W | 2.5 | 46.5 | Lincoln Financial Field |
| 2025-11-23 | 12 | @ | DAL | 21-24 | L | -3 | 47.5 | AT&T Stadium |
| 2025-11-28 | 13 | vs | CHI | 15-24 | L | 7 | 43.5 | Lincoln Financial Field |
| 2025-12-08 | 14 | @ | LAC | 19-22 | L | -1.5 | 41.5 | SoFi Stadium |
| 2025-12-14 | 15 | vs | LV | 31-0 | W | 12.5 | 37.5 | Lincoln Financial Field |
| 2025-12-20 | 16 | @ | WAS | 29-18 | W | -7 | 43.5 | FedExField |
| 2025-12-28 | 17 | @ | BUF | 13-12 | W | 3 | 45.5 | New Era Field |
| 2026-01-04 | 18 | vs | WAS | 17-24 | L | 3 | 38.5 | Lincoln Financial Field |
| 2026-01-11 | 19 | vs | SF | 19-23 | L | 6 | 44.5 | Lincoln Financial Field |
