| 2009-09-13 | 1 | @ |  CLE | 34-20 | W | -4 | 39.5 | Cleveland Browns Stadium |
| 2009-09-20 | 2 | @ |  DET | 27-13 | W | -10 | 45 | Ford Field |
| 2009-09-27 | 3 | vs |  SF | 27-24 | W | 7 | 39 | Hubert H. Humphrey Metrodome |
| 2009-10-05 | 4 | vs |  GB | 30-23 | W | 4.5 | 46 | Hubert H. Humphrey Metrodome |
| 2009-10-11 | 5 | @ |  STL | 38-10 | W | -10 | 40.5 | Edward Jones Dome |
| 2009-10-18 | 6 | vs |  BAL | 33-31 | W | 3 | 45.5 | Hubert H. Humphrey Metrodome |
| 2009-10-25 | 7 | @ |  PIT | 17-27 | L | 6 | 46.5 | Heinz Field |
| 2009-11-01 | 8 | @ | GB | 38-26 | W | 3.5 | 46.5 | Lambeau Field |
| 2009-11-15 | 10 | vs | DET | 27-10 | W | 17 | 47.5 | Hubert H. Humphrey Metrodome |
| 2009-11-22 | 11 | vs |  SEA | 35-9 | W | 10.5 | 47 | Hubert H. Humphrey Metrodome |
| 2009-11-29 | 12 | vs |  CHI | 36-10 | W | 10 | 47 | Hubert H. Humphrey Metrodome |
| 2009-12-06 | 13 | @ |  ARI | 17-30 | L | -3.5 | 48 | University of Phoenix Stadium |
| 2009-12-13 | 14 | vs |  CIN | 30-10 | W | 6 | 42.5 | Hubert H. Humphrey Metrodome |
| 2009-12-20 | 15 | @ |  CAR | 7-26 | L | -9 | 42.5 | Bank of America Stadium |
| 2009-12-28 | 16 | @ | CHI | 30-36 | L | -9 | 41 | Soldier Field |
| 2010-01-03 | 17 | vs |  NYG | 44-7 | W | 9 | 48 | Hubert H. Humphrey Metrodome |
| 2010-01-17 | 19 | vs |  DAL | 34-3 | W | 2.5 | 45 | Hubert H. Humphrey Metrodome |
| 2010-01-24 | 20 | @ |  NO | 28-31 | L | 4 | 54 | Louisiana Superdome |
