| 2008-09-08 | 1 | @ |  GB | 19-24 | L | 2.5 | 37.5 | Lambeau Field |
| 2008-09-14 | 2 | vs |  IND | 15-18 | L | -1 | 43.5 | Hubert H. Humphrey Metrodome |
| 2008-09-21 | 3 | vs |  CAR | 20-10 | W | 3 | 37.5 | Hubert H. Humphrey Metrodome |
| 2008-09-28 | 4 | @ |  TEN | 17-30 | L | 3 | 35 | LP Field |
| 2008-10-06 | 5 | @ |  NO | 30-27 | W | 3 | 47 | Louisiana Superdome |
| 2008-10-12 | 6 | vs |  DET | 12-10 | W | 13 | 44.5 | Hubert H. Humphrey Metrodome |
| 2008-10-19 | 7 | @ |  CHI | 41-48 | L | 3 | 38 | Soldier Field |
| 2008-11-02 | 9 | vs |  HOU | 28-21 | W | 6.5 | 46.5 | Hubert H. Humphrey Metrodome |
| 2008-11-09 | 10 | vs | GB | 28-27 | W | 2.5 | 44 | Hubert H. Humphrey Metrodome |
| 2008-11-16 | 11 | @ |  TB | 13-19 | L | 4.5 | 39.5 | Raymond James Stadium |
| 2008-11-23 | 12 | @ |  JAX | 30-12 | W | 1 | 41.5 | Jacksonville Municipal Stadium |
| 2008-11-30 | 13 | vs | CHI | 34-14 | W | 5 | 41.5 | Hubert H. Humphrey Metrodome |
| 2008-12-07 | 14 | @ | DET | 20-16 | W | -10.5 | 45 | Ford Field |
| 2008-12-14 | 15 | @ |  ARI | 35-14 | W | 4 | 46.5 | University of Phoenix Stadium |
| 2008-12-21 | 16 | vs |  ATL | 17-24 | L | 3 | 43 | Hubert H. Humphrey Metrodome |
| 2008-12-28 | 17 | vs |  NYG | 20-19 | W | 7 | 41 | Hubert H. Humphrey Metrodome |
| 2009-01-04 | 18 | vs |  PHI | 14-26 | L | -3 | 40.5 | Hubert H. Humphrey Metrodome |
