| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | vs | HOU | 14-9 | W | 3.5 | 43.5 | SoFi Stadium |
| 2025-09-14 | 2 | @ | TEN | 33-19 | W | -5.5 | 41.5 | Nissan Stadium |
| 2025-09-21 | 3 | @ | PHI | 26-33 | L | 3.5 | 45.5 | Lincoln Financial Field |
| 2025-09-28 | 4 | vs | IND | 27-20 | W | 3.5 | 49.5 | SoFi Stadium |
| 2025-10-02 | 5 | vs | SF | 23-26 | L | 8.5 | 43.5 | SoFi Stadium |
| 2025-10-12 | 6 | @ | BAL | 17-3 | W | -7 | 43.5 | M&T Bank Stadium |
| 2025-10-19 | 7 | @ | JAX | 35-7 | W | -3 | 44.5 | TIAA Bank Stadium |
| 2025-11-02 | 9 | vs | NO | 34-10 | W | 14 | 44.5 | SoFi Stadium |
| 2025-11-09 | 10 | @ | SF | 42-26 | W | -5.5 | 49.5 | Levi's Stadium |
| 2025-11-16 | 11 | vs | SEA | 21-19 | W | 3 | 49.5 | SoFi Stadium |
| 2025-11-23 | 12 | vs | TB | 34-7 | W | 7 | 49.5 | SoFi Stadium |
| 2025-11-30 | 13 | @ | CAR | 28-31 | L | -10 | 44.5 | Bank of America Stadium |
| 2025-12-07 | 14 | @ | ARI | 45-17 | W | -9.5 | 49.5 | State Farm Stadium |
| 2025-12-14 | 15 | vs | DET | 41-34 | W | 5.5 | 54.5 | SoFi Stadium |
| 2025-12-18 | 16 | @ | SEA | 37-38 | L | 1.5 | 42.5 | Lumen Field |
| 2025-12-29 | 17 | @ | ATL | 24-27 | L | -7.5 | 48.5 | Mercedes-Benz Stadium |
| 2026-01-04 | 18 | vs | ARI | 37-20 | W | 14.5 | 49.5 | SoFi Stadium |
| 2026-01-10 | 19 | @ | CAR | 34-31 | W | -10 | 44.5 | Bank of America Stadium |
| 2026-01-18 | 20 | @ | CHI | 20-17 | W | -3.5 | 49.5 | Soldier Field |
| 2026-01-25 | 21 | @ | SEA | 27-31 | L | 2.5 | 45.5 | Lumen Field |
