| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-05 | 1 | vs | KC | 27-21 | W | -3 | 47.5 | SoFi Stadium |
| 2025-09-15 | 2 | @ | LV | 20-9 | W | -3.5 | 46.5 | Allegiant Stadium |
| 2025-09-21 | 3 | vs | DEN | 23-20 | W | 2.5 | 45.5 | SoFi Stadium |
| 2025-09-28 | 4 | @ | NYG | 18-21 | L | -6 | 43.5 | MetLife Stadium |
| 2025-10-05 | 5 | vs | WAS | 10-27 | L | 2.5 | 47.5 | SoFi Stadium |
| 2025-10-12 | 6 | @ | MIA | 29-27 | W | -3.5 | 45.5 | Hard Rock Stadium |
| 2025-10-19 | 7 | vs | IND | 24-38 | L | 2.5 | 48.5 | SoFi Stadium |
| 2025-10-23 | 8 | vs | MIN | 37-10 | W | 3 | 45.5 | SoFi Stadium |
| 2025-11-02 | 9 | @ | TEN | 27-20 | W | -10 | 44.5 | Nissan Stadium |
| 2025-11-09 | 10 | vs | PIT | 25-10 | W | 3 | 45.5 | SoFi Stadium |
| 2025-11-16 | 11 | @ | JAX | 6-35 | L | -3 | 43.5 | TIAA Bank Stadium |
| 2025-11-30 | 13 | vs | LV | 31-14 | W | 10 | 40.5 | SoFi Stadium |
| 2025-12-08 | 14 | vs | PHI | 22-19 | W | -1.5 | 41.5 | SoFi Stadium |
| 2025-12-14 | 15 | @ | KC | 16-13 | W | 5.5 | 41.5 | GEHA Field at Arrowhead Stadium |
| 2025-12-21 | 16 | @ | DAL | 34-17 | W | 1.5 | 50.5 | AT&T Stadium |
| 2025-12-27 | 17 | vs | HOU | 16-20 | L | 1.5 | 40.5 | SoFi Stadium |
| 2026-01-04 | 18 | @ | DEN | 3-19 | L | 14.5 | 37.5 | Empower Field at Mile High |
| 2026-01-11 | 19 | @ | NE | 3-16 | L | 3.5 | 45.5 | Gillette Stadium |
