| 2025-09-05 | 1 | @ |  LAC | 21-27 | L | -3 | 47.5 | SoFi Stadium |
| 2025-09-14 | 2 | vs |  PHI | 17-20 | L | -1.5 | 46.5 | GEHA Field at Arrowhead Stadium |
| 2025-09-21 | 3 | @ |  NYG | 22-9 | W | -6 | 44.5 | MetLife Stadium |
| 2025-09-28 | 4 | vs |  BAL | 37-20 | W | -2.5 | 48.5 | GEHA Field at Arrowhead Stadium |
| 2025-10-06 | 5 | @ |  JAX | 28-31 | L | -3.5 | 45.5 | TIAA Bank Stadium |
| 2025-10-12 | 6 | vs |  DET | 30-17 | W | 2.5 | 51.5 | GEHA Field at Arrowhead Stadium |
| 2025-10-19 | 7 | vs |  LV | 31-0 | W | 13.5 | 44.5 | GEHA Field at Arrowhead Stadium |
| 2025-10-27 | 8 | vs |  WAS | 28-7 | W | 10.5 | 48.5 | GEHA Field at Arrowhead Stadium |
| 2025-11-02 | 9 | @ |  BUF | 21-28 | L | -2.5 | 53.5 | New Era Field |
| 2025-11-16 | 11 | @ |  DEN | 19-22 | L | -3.5 | 44.5 | Empower Field at Mile High |
| 2025-11-23 | 12 | vs |  IND | 23-20 | W | 3.5 | 50.5 | GEHA Field at Arrowhead Stadium |
| 2025-11-27 | 13 | @ |  DAL | 28-31 | L | -3.5 | 53.5 | AT&T Stadium |
| 2025-12-07 | 14 | vs |  HOU | 10-20 | L | 4.5 | 41.5 | GEHA Field at Arrowhead Stadium |
| 2025-12-14 | 15 | vs | LAC | 13-16 | L | 5.5 | 41.5 | GEHA Field at Arrowhead Stadium |
| 2025-12-21 | 16 | @ |  TEN | 9-26 | L | -3.5 | 37.5 | Nissan Stadium |
| 2025-12-25 | 17 | vs | DEN | 13-20 | L | -13.5 | 37.5 | GEHA Field at Arrowhead Stadium |
| 2026-01-04 | 18 | @ | LV | 12-14 | L | -3.5 | 36.5 | Allegiant Stadium |
