| 2024-09-05 | 1 | vs |  BAL | 27-20 | W | 3 | 46 | GEHA Field at Arrowhead Stadium |
| 2024-09-15 | 2 | vs |  CIN | 26-25 | W | 6.5 | 47.5 | GEHA Field at Arrowhead Stadium |
| 2024-09-22 | 3 | @ |  ATL | 22-17 | W | -3 | 46 | Mercedes-Benz Stadium |
| 2024-09-29 | 4 | @ |  LAC | 17-10 | W | -7.5 | 41.5 | SoFi Stadium |
| 2024-10-07 | 5 | vs |  NO | 26-13 | W | 5.5 | 43 | GEHA Field at Arrowhead Stadium |
| 2024-10-20 | 7 | @ |  SF | 28-18 | W | 2.5 | 47.5 | Levi's Stadium |
| 2024-10-27 | 8 | @ |  LV | 27-20 | W | -9 | 42 | Allegiant Stadium |
| 2024-11-04 | 9 | vs |  TB | 30-24 | W | 9 | 45.5 | GEHA Field at Arrowhead Stadium |
| 2024-11-10 | 10 | vs |  DEN | 16-14 | W | 7.5 | 42.5 | GEHA Field at Arrowhead Stadium |
| 2024-11-17 | 11 | @ |  BUF | 21-30 | L | 2.5 | 46.5 | New Era Field |
| 2024-11-24 | 12 | @ |  CAR | 30-27 | W | -11 | 43 | Bank of America Stadium |
| 2024-11-29 | 13 | vs | LV | 19-17 | W | 13.5 | 42 | GEHA Field at Arrowhead Stadium |
| 2024-12-08 | 14 | vs | LAC | 19-17 | W | 5 | 43.5 | GEHA Field at Arrowhead Stadium |
| 2024-12-15 | 15 | @ |  CLE | 21-7 | W | -4.5 | 41.5 | FirstEnergy Stadium |
| 2024-12-21 | 16 | vs |  HOU | 27-19 | W | 3.5 | 42.5 | GEHA Field at Arrowhead Stadium |
| 2024-12-25 | 17 | @ |  PIT | 29-10 | W | -3 | 43.5 | Acrisure Stadium |
| 2025-01-05 | 18 | @ | DEN | 0-38 | L | 10.5 | 40.5 | Empower Field at Mile High |
| 2025-01-18 | 20 | vs | HOU | 23-14 | W | 9.5 | 41.5 | GEHA Field at Arrowhead Stadium |
| 2025-01-26 | 21 | vs | BUF | 32-29 | W | 1.5 | 49.5 | GEHA Field at Arrowhead Stadium |
| 2025-02-09 | 22 | @ |  PHI | 22-40 | L | -1.5 | 48.5 | Mercedes-Benz Superdome |
