| 2023-09-07 | 1 | vs |  DET | 20-21 | L | 4 | 53 | GEHA Field at Arrowhead Stadium |
| 2023-09-17 | 2 | @ |  JAX | 17-9 | W | -3.5 | 50.5 | TIAA Bank Stadium |
| 2023-09-24 | 3 | vs |  CHI | 41-10 | W | 13 | 48 | GEHA Field at Arrowhead Stadium |
| 2023-10-01 | 4 | @ |  NYJ | 23-20 | W | -9.5 | 41.5 | MetLife Stadium |
| 2023-10-08 | 5 | @ |  MIN | 27-20 | W | -3.5 | 52.5 | U.S. Bank Stadium |
| 2023-10-12 | 6 | vs |  DEN | 19-8 | W | 10.5 | 47.5 | GEHA Field at Arrowhead Stadium |
| 2023-10-22 | 7 | vs |  LAC | 31-17 | W | 5.5 | 48.5 | GEHA Field at Arrowhead Stadium |
| 2023-10-29 | 8 | @ | DEN | 9-24 | L | -7 | 45.5 | Empower Field at Mile High |
| 2023-11-05 | 9 | vs |  MIA | 21-14 | W | 1 | 51 | Deutsche Bank Park |
| 2023-11-20 | 11 | vs |  PHI | 17-21 | L | 2.5 | 46 | GEHA Field at Arrowhead Stadium |
| 2023-11-26 | 12 | @ |  LV | 31-17 | W | -9 | 42.5 | Allegiant Stadium |
| 2023-12-03 | 13 | @ |  GB | 19-27 | L | -5.5 | 43.5 | Lambeau Field |
| 2023-12-10 | 14 | vs |  BUF | 17-20 | L | 2 | 49.5 | GEHA Field at Arrowhead Stadium |
| 2023-12-17 | 15 | @ |  NE | 27-17 | W | -10 | 39.5 | Gillette Stadium |
| 2023-12-25 | 16 | vs | LV | 14-20 | L | 11 | 40.5 | GEHA Field at Arrowhead Stadium |
| 2023-12-31 | 17 | vs |  CIN | 25-17 | W | 7.5 | 46 | GEHA Field at Arrowhead Stadium |
| 2024-01-07 | 18 | @ | LAC | 13-12 | W | 3.5 | 35 | SoFi Stadium |
| 2024-01-13 | 19 | vs | MIA | 26-7 | W | 4.5 | 43.5 | GEHA Field at Arrowhead Stadium |
| 2024-01-21 | 20 | @ | BUF | 27-24 | W | 2.5 | 45.5 | New Era Field |
| 2024-01-28 | 21 | @ |  BAL | 17-10 | W | 4.5 | 44 | M&T Bank Stadium |
| 2024-02-11 | 22 | vs |  SF | 25-22 | W | -1.5 | 47 | Allegiant Stadium |
