| 2022-09-11 | 1 | @ |  ARI | 44-21 | W | -6 | 54 | State Farm Stadium |
| 2022-09-15 | 2 | vs |  LAC | 27-24 | W | 4 | 52.5 | GEHA Field at Arrowhead Stadium |
| 2022-09-25 | 3 | @ |  IND | 17-20 | L | -4.5 | 51 | Lucas Oil Stadium |
| 2022-10-02 | 4 | @ |  TB | 41-31 | W | 1 | 46.5 | Raymond James Stadium |
| 2022-10-10 | 5 | vs |  LV | 30-29 | W | 7.5 | 51.5 | GEHA Field at Arrowhead Stadium |
| 2022-10-16 | 6 | vs |  BUF | 20-24 | L | -2.5 | 54 | GEHA Field at Arrowhead Stadium |
| 2022-10-23 | 7 | @ |  SF | 44-23 | W | -1 | 49 | Levi's Stadium |
| 2022-11-06 | 9 | vs |  TEN | 20-17 | W | 14 | 45 | GEHA Field at Arrowhead Stadium |
| 2022-11-13 | 10 | vs |  JAX | 27-17 | W | 10 | 51.5 | GEHA Field at Arrowhead Stadium |
| 2022-11-20 | 11 | @ | LAC | 30-27 | W | -5.5 | 52.5 | SoFi Stadium |
| 2022-11-27 | 12 | vs |  LA | 26-10 | W | 16.5 | 42 | GEHA Field at Arrowhead Stadium |
| 2022-12-04 | 13 | @ |  CIN | 24-27 | L | -2.5 | 53 | Paycor Stadium |
| 2022-12-11 | 14 | @ |  DEN | 34-28 | W | -8.5 | 44.5 | Empower Field at Mile High |
| 2022-12-18 | 15 | @ |  HOU | 30-24 | W | -14.5 | 48.5 | NRG Stadium |
| 2022-12-24 | 16 | vs |  SEA | 24-10 | W | 10.5 | 50.5 | GEHA Field at Arrowhead Stadium |
| 2023-01-01 | 17 | vs | DEN | 27-24 | W | 13.5 | 46 | GEHA Field at Arrowhead Stadium |
| 2023-01-07 | 18 | @ | LV | 31-13 | W | -9 | 51.5 | Allegiant Stadium |
| 2023-01-21 | 20 | vs | JAX | 27-20 | W | 10 | 52.5 | GEHA Field at Arrowhead Stadium |
| 2023-01-29 | 21 | vs | CIN | 23-20 | W | 2 | 48.5 | GEHA Field at Arrowhead Stadium |
| 2023-02-12 | 22 | @ |  PHI | 38-35 | W | 1 | 51 | State Farm Stadium |
