| 2023-09-10 | 1 | vs |  LV | 16-17 | L | 3 | 43 | Empower Field at Mile High |
| 2023-09-17 | 2 | vs |  WAS | 33-35 | L | 4 | 38.5 | Empower Field at Mile High |
| 2023-09-24 | 3 | @ |  MIA | 20-70 | L | 6 | 47.5 | Hard Rock Stadium |
| 2023-10-01 | 4 | @ |  CHI | 31-28 | W | -3 | 47 | Soldier Field |
| 2023-10-08 | 5 | vs |  NYJ | 21-31 | L | 2.5 | 42.5 | Empower Field at Mile High |
| 2023-10-12 | 6 | @ |  KC | 8-19 | L | 10.5 | 47.5 | GEHA Field at Arrowhead Stadium |
| 2023-10-22 | 7 | vs |  GB | 19-17 | W | 1.5 | 44 | Empower Field at Mile High |
| 2023-10-29 | 8 | vs | KC | 24-9 | W | -7 | 45.5 | Empower Field at Mile High |
| 2023-11-13 | 10 | @ |  BUF | 24-22 | W | 7.5 | 47.5 | New Era Field |
| 2023-11-19 | 11 | vs |  MIN | 21-20 | W | 2.5 | 43.5 | Empower Field at Mile High |
| 2023-11-26 | 12 | vs |  CLE | 29-12 | W | 1.5 | 37.5 | Empower Field at Mile High |
| 2023-12-03 | 13 | @ |  HOU | 17-22 | L | 3.5 | 47.5 | NRG Stadium |
| 2023-12-10 | 14 | @ |  LAC | 24-7 | W | 3 | 45 | SoFi Stadium |
| 2023-12-16 | 15 | @ |  DET | 17-42 | L | 5.5 | 49 | Ford Field |
| 2023-12-24 | 16 | vs |  NE | 23-26 | L | 7 | 37.5 | Empower Field at Mile High |
| 2023-12-31 | 17 | vs | LAC | 16-9 | W | 3.5 | 39.5 | Empower Field at Mile High |
| 2024-01-07 | 18 | @ | LV | 14-27 | L | 3.5 | 37.5 | Allegiant Stadium |
