| 2018-09-09 | 1 | vs |  SEA | 27-24 | W | 3 | 42.5 | Sports Authority Field at Mile High |
| 2018-09-16 | 2 | vs |  OAK | 20-19 | W | 5.5 | 44.5 | Sports Authority Field at Mile High |
| 2018-09-23 | 3 | @ |  BAL | 14-27 | L | 5.5 | 46 | M&T Bank Stadium |
| 2018-10-01 | 4 | vs |  KC | 23-27 | L | -3.5 | 53.5 | Sports Authority Field at Mile High |
| 2018-10-07 | 5 | @ |  NYJ | 16-34 | L | -1 | 42 | MetLife Stadium |
| 2018-10-14 | 6 | vs |  LA | 20-23 | L | -7 | 50 | Sports Authority Field at Mile High |
| 2018-10-18 | 7 | @ |  ARI | 45-10 | W | -1 | 42.5 | State Farm Stadium |
| 2018-10-28 | 8 | @ | KC | 23-30 | L | 8.5 | 53 | Arrowhead Stadium |
| 2018-11-04 | 9 | vs |  HOU | 17-19 | L | 1 | 46.5 | Sports Authority Field at Mile High |
| 2018-11-18 | 11 | @ |  LAC | 23-22 | W | 7.5 | 47 | StubHub Center |
| 2018-11-25 | 12 | vs |  PIT | 24-17 | W | -3 | 47.5 | Sports Authority Field at Mile High |
| 2018-12-02 | 13 | @ |  CIN | 24-10 | W | -3.5 | 45 | Paul Brown Stadium |
| 2018-12-09 | 14 | @ |  SF | 14-20 | L | -3 | 45.5 | Levi's Stadium |
| 2018-12-15 | 15 | vs |  CLE | 16-17 | L | 1 | 47 | Sports Authority Field at Mile High |
| 2018-12-24 | 16 | @ | OAK | 14-27 | L | -2.5 | 42.5 | Oakland-Alameda County Coliseum |
| 2018-12-30 | 17 | vs | LAC | 9-23 | L | -7 | 43.5 | Sports Authority Field at Mile High |
