| 2016-09-08 | 1 | vs |  CAR | 21-20 | W | -3 | 40.5 | Sports Authority Field at Mile High |
| 2016-09-18 | 2 | vs |  IND | 34-20 | W | 5 | 47 | Sports Authority Field at Mile High |
| 2016-09-25 | 3 | @ |  CIN | 29-17 | W | 3.5 | 42 | Paul Brown Stadium |
| 2016-10-02 | 4 | @ |  TB | 27-7 | W | -3.5 | 43 | Raymond James Stadium |
| 2016-10-09 | 5 | vs |  ATL | 16-23 | L | 3.5 | 44.5 | Sports Authority Field at Mile High |
| 2016-10-13 | 6 | @ |  SD | 13-21 | L | -3 | 44 | Qualcomm Stadium |
| 2016-10-24 | 7 | vs |  HOU | 27-9 | W | 8.5 | 40 | Sports Authority Field at Mile High |
| 2016-10-30 | 8 | vs | SD | 27-19 | W | 3.5 | 43 | Sports Authority Field at Mile High |
| 2016-11-06 | 9 | @ |  OAK | 20-30 | L | 1 | 44.5 | Oakland-Alameda County Coliseum |
| 2016-11-13 | 10 | @ |  NO | 25-23 | W | 3 | 50 | Mercedes-Benz Superdome |
| 2016-11-27 | 12 | vs |  KC | 27-30 | L | 3.5 | 40 | Sports Authority Field at Mile High |
| 2016-12-04 | 13 | @ |  JAX | 20-10 | W | -3.5 | 39 | EverBank Field |
| 2016-12-11 | 14 | @ |  TEN | 10-13 | L | 2 | 44 | Nissan Stadium |
| 2016-12-18 | 15 | vs |  NE | 3-16 | L | -3 | 43.5 | Sports Authority Field at Mile High |
| 2016-12-25 | 16 | @ | KC | 10-33 | L | 3.5 | 38.5 | Arrowhead Stadium |
| 2017-01-01 | 17 | vs | OAK | 24-6 | W | 1 | 40 | Sports Authority Field at Mile High |
