| 2015-09-13 | 1 | vs |  BAL | 19-13 | W | 4.5 | 46.5 | Sports Authority Field at Mile High |
| 2015-09-17 | 2 | @ |  KC | 31-24 | W | 3 | 42 | Arrowhead Stadium |
| 2015-09-27 | 3 | @ |  DET | 24-12 | W | -3 | 45 | Ford Field |
| 2015-10-04 | 4 | vs |  MIN | 23-20 | W | 7 | 43.5 | Sports Authority Field at Mile High |
| 2015-10-11 | 5 | @ |  OAK | 16-10 | W | -5 | 44.5 | O.co Coliseum |
| 2015-10-18 | 6 | @ |  CLE | 26-23 | W | -3.5 | 41.5 | FirstEnergy Stadium |
| 2015-11-01 | 8 | vs |  GB | 29-10 | W | -2.5 | 46 | Sports Authority Field at Mile High |
| 2015-11-08 | 9 | @ |  IND | 24-27 | L | -3.5 | 45 | Lucas Oil Stadium |
| 2015-11-15 | 10 | vs | KC | 13-29 | L | 4 | 42 | Sports Authority Field at Mile High |
| 2015-11-22 | 11 | @ |  CHI | 17-15 | W | -2.5 | 41.5 | Soldier Field |
| 2015-11-29 | 12 | vs |  NE | 30-24 | W | -2.5 | 43 | Sports Authority Field at Mile High |
| 2015-12-06 | 13 | @ |  SD | 17-3 | W | -6 | 45 | Qualcomm Stadium |
| 2015-12-13 | 14 | vs | OAK | 12-15 | L | 6 | 43 | Sports Authority Field at Mile High |
| 2015-12-20 | 15 | @ |  PIT | 27-34 | L | 7.5 | 45.5 | Heinz Field |
| 2015-12-28 | 16 | vs |  CIN | 20-17 | W | 3.5 | 39 | Sports Authority Field at Mile High |
| 2016-01-03 | 17 | vs | SD | 27-20 | W | 10 | 42 | Sports Authority Field at Mile High |
| 2016-01-17 | 19 | vs | PIT | 23-16 | W | 7 | 41.5 | Sports Authority Field at Mile High |
| 2016-01-24 | 20 | vs | NE | 20-18 | W | -2.5 | 45 | Sports Authority Field at Mile High |
| 2016-02-07 | 21 | vs |  CAR | 24-10 | W | -4.5 | 43 | Levi's Stadium |
