| 2014-09-07 | 1 | vs |  IND | 31-24 | W | 8 | 52.5 | Sports Authority Field at Mile High |
| 2014-09-14 | 2 | vs |  KC | 24-17 | W | 13 | 49 | Sports Authority Field at Mile High |
| 2014-09-21 | 3 | @ |  SEA | 20-26 | L | 4 | 48 | CenturyLink Field |
| 2014-10-05 | 5 | vs |  ARI | 41-20 | W | 8 | 47 | Sports Authority Field at Mile High |
| 2014-10-12 | 6 | @ |  NYJ | 31-17 | W | -10 | 47 | MetLife Stadium |
| 2014-10-19 | 7 | vs |  SF | 42-17 | W | 7 | 48 | Sports Authority Field at Mile High |
| 2014-10-23 | 8 | vs |  SD | 35-21 | W | 9 | 51 | Sports Authority Field at Mile High |
| 2014-11-02 | 9 | @ |  NE | 21-43 | L | -3 | 52.5 | Gillette Stadium |
| 2014-11-09 | 10 | @ |  OAK | 41-17 | W | -13 | 50.5 | O.co Coliseum |
| 2014-11-16 | 11 | @ |  STL | 7-22 | L | -8 | 49.5 | Edward Jones Dome |
| 2014-11-23 | 12 | vs |  MIA | 39-36 | W | 6.5 | 47.5 | Sports Authority Field at Mile High |
| 2014-11-30 | 13 | @ | KC | 29-16 | W | 1 | 49 | Arrowhead Stadium |
| 2014-12-07 | 14 | vs |  BUF | 24-17 | W | 9 | 47 | Sports Authority Field at Mile High |
| 2014-12-14 | 15 | @ | SD | 22-10 | W | -4 | 49 | Qualcomm Stadium |
| 2014-12-22 | 16 | @ |  CIN | 28-37 | L | -3.5 | 47 | Paul Brown Stadium |
| 2014-12-28 | 17 | vs | OAK | 47-14 | W | 16.5 | 49 | Sports Authority Field at Mile High |
| 2015-01-11 | 19 | vs | IND | 13-24 | L | 9.5 | 53.5 | Sports Authority Field at Mile High |
