| 2013-09-05 | 1 | vs |  BAL | 49-27 | W | 7.5 | 48.5 | Sports Authority Field at Mile High |
| 2013-09-15 | 2 | @ |  NYG | 41-23 | W | -3.5 | 52.5 | MetLife Stadium |
| 2013-09-23 | 3 | vs |  OAK | 37-21 | W | 16 | 48.5 | Sports Authority Field at Mile High |
| 2013-09-29 | 4 | vs |  PHI | 52-20 | W | 10.5 | 57.5 | Sports Authority Field at Mile High |
| 2013-10-06 | 5 | @ |  DAL | 51-48 | W | -7.5 | 56.5 | AT&T Stadium |
| 2013-10-13 | 6 | vs |  JAX | 35-19 | W | 27 | 53 | Sports Authority Field at Mile High |
| 2013-10-20 | 7 | @ |  IND | 33-39 | L | -6 | 54.5 | Lucas Oil Stadium |
| 2013-10-27 | 8 | vs |  WAS | 45-21 | W | 11 | 58 | Sports Authority Field at Mile High |
| 2013-11-10 | 10 | @ |  SD | 28-20 | W | -7 | 56 | Qualcomm Stadium |
| 2013-11-17 | 11 | vs |  KC | 27-17 | W | 7.5 | 48.5 | Sports Authority Field at Mile High |
| 2013-11-24 | 12 | @ |  NE | 31-34 | L | 1 | 54 | Gillette Stadium |
| 2013-12-01 | 13 | @ | KC | 35-28 | W | -5 | 50.5 | Arrowhead Stadium |
| 2013-12-08 | 14 | vs |  TEN | 51-28 | W | 13 | 49.5 | Sports Authority Field at Mile High |
| 2013-12-12 | 15 | vs | SD | 20-27 | L | 10 | 56.5 | Sports Authority Field at Mile High |
| 2013-12-22 | 16 | @ |  HOU | 37-13 | W | -9 | 53 | Reliant Stadium |
| 2013-12-29 | 17 | @ | OAK | 34-14 | W | -10 | 53.5 | O.co Coliseum |
| 2014-01-12 | 19 | vs | SD | 24-17 | W | 8 | 55 | Sports Authority Field at Mile High |
| 2014-01-19 | 20 | vs | NE | 26-16 | W | 5 | 56.5 | Sports Authority Field at Mile High |
| 2014-02-02 | 21 | vs |  SEA | 8-43 | L | 1.5 | 47 | MetLife Stadium |
