| 2012-09-09 | 1 | vs |  PIT | 31-19 | W | 2.5 | 45.5 | Sports Authority Field at Mile High |
| 2012-09-17 | 2 | @ |  ATL | 21-27 | L | 3 | 50 | Georgia Dome |
| 2012-09-23 | 3 | vs |  HOU | 25-31 | L | -1 | 43.5 | Sports Authority Field at Mile High |
| 2012-09-30 | 4 | vs |  OAK | 37-6 | W | 6.5 | 47 | Sports Authority Field at Mile High |
| 2012-10-07 | 5 | @ |  NE | 21-31 | L | 6 | 50.5 | Gillette Stadium |
| 2012-10-15 | 6 | @ |  SD | 35-24 | W | 1 | 47.5 | Qualcomm Stadium |
| 2012-10-28 | 8 | vs |  NO | 34-14 | W | 6 | 55 | Sports Authority Field at Mile High |
| 2012-11-04 | 9 | @ |  CIN | 31-23 | W | -5 | 47.5 | Paul Brown Stadium |
| 2012-11-11 | 10 | @ |  CAR | 36-14 | W | -3.5 | 46.5 | Bank of America Stadium |
| 2012-11-18 | 11 | vs | SD | 30-23 | W | 7.5 | 47.5 | Sports Authority Field at Mile High |
| 2012-11-25 | 12 | @ |  KC | 17-9 | W | -10 | 41.5 | Arrowhead Stadium |
| 2012-12-02 | 13 | vs |  TB | 31-23 | W | 9.5 | 50 | Sports Authority Field at Mile High |
| 2012-12-06 | 14 | @ | OAK | 26-13 | W | -10 | 47 | O.co Coliseum |
| 2012-12-16 | 15 | @ |  BAL | 34-17 | W | -3 | 48 | M&T Bank Stadium |
| 2012-12-23 | 16 | vs |  CLE | 34-12 | W | 11 | 43.5 | Sports Authority Field at Mile High |
| 2012-12-30 | 17 | vs | KC | 38-3 | W | 17 | 41 | Sports Authority Field at Mile High |
| 2013-01-12 | 19 | vs | BAL | 35-38 | L | 9.5 | 44 | Sports Authority Field at Mile High |
