| 2011-09-12 | 1 | vs | OAK | 20-23 | L | 3 | 42.5 | Sports Authority Field at Mile High |
| 2011-09-18 | 2 | vs | CIN | 24-22 | W | 3.5 | 40.5 | Sports Authority Field at Mile High |
| 2011-09-25 | 3 | @ | TEN | 14-17 | L | 7 | 43.5 | LP Field |
| 2011-10-02 | 4 | @ | GB | 23-49 | L | 12 | 46.5 | Lambeau Field |
| 2011-10-09 | 5 | vs | SD | 24-29 | L | -3.5 | 47 | Sports Authority Field at Mile High |
| 2011-10-23 | 7 | @ | MIA | 18-15 | W | -1 | 41.5 | Sun Life Stadium |
| 2011-10-30 | 8 | vs | DET | 10-45 | L | -3 | 43.5 | Sports Authority Field at Mile High |
| 2011-11-06 | 9 | @ | OAK | 38-24 | W | 7 | 41.5 | O.co Coliseum |
| 2011-11-13 | 10 | @ | KC | 17-10 | W | 3 | 42 | Arrowhead Stadium |
| 2011-11-17 | 11 | vs | NYJ | 17-13 | W | -6.5 | 38.5 | Sports Authority Field at Mile High |
| 2011-11-27 | 12 | @ | SD | 16-13 | W | 4.5 | 42.5 | Qualcomm Stadium |
| 2011-12-04 | 13 | @ | MIN | 35-32 | W | 1 | 37.5 | Mall of America Field |
| 2011-12-11 | 14 | vs | CHI | 13-10 | W | 3.5 | 35 | Sports Authority Field at Mile High |
| 2011-12-18 | 15 | vs | NE | 23-41 | L | -7 | 47.5 | Sports Authority Field at Mile High |
| 2011-12-24 | 16 | @ | BUF | 14-40 | L | -3 | 43.5 | Ralph Wilson Stadium |
| 2012-01-01 | 17 | vs | KC | 3-7 | L | 1 | 37 | Sports Authority Field at Mile High |
| 2012-01-08 | 18 | vs | PIT | 29-23 | W | -7.5 | 34 | Sports Authority Field at Mile High |
| 2012-01-14 | 19 | @ | NE | 10-45 | L | 14 | 50 | Gillette Stadium |