| 2005-09-11 | 1 | @ |  MIA | 10-34 | L | -4.5 | 38.5 | Dolphin Stadium |
| 2005-09-18 | 2 | vs |  SD | 20-17 | W | 3 | 44 | Invesco Field at Mile High |
| 2005-09-26 | 3 | vs |  KC | 30-10 | W | 2.5 | 49 | Invesco Field at Mile High |
| 2005-10-02 | 4 | @ |  JAX | 20-7 | W | 4 | 37.5 | Alltel Stadium |
| 2005-10-09 | 5 | vs |  WAS | 21-19 | W | 7 | 34.5 | Invesco Field at Mile High |
| 2005-10-16 | 6 | vs |  NE | 28-20 | W | 3 | 44 | Invesco Field at Mile High |
| 2005-10-23 | 7 | @ |  NYG | 23-24 | L | 2 | 46.5 | Giants Stadium |
| 2005-10-30 | 8 | vs |  PHI | 49-21 | W | 3 | 44 | Invesco Field at Mile High |
| 2005-11-13 | 10 | @ |  OAK | 31-17 | W | -2.5 | 47 | McAfee Coliseum |
| 2005-11-20 | 11 | vs |  NYJ | 27-0 | W | 13 | 41 | Invesco Field at Mile High |
| 2005-11-24 | 12 | @ |  DAL | 24-21 | W | 1.5 | 41 | Texas Stadium |
| 2005-12-04 | 13 | @ | KC | 27-31 | L | 0 | 47 | Arrowhead Stadium |
| 2005-12-11 | 14 | vs |  BAL | 12-10 | W | 14 | 40.5 | Invesco Field at Mile High |
| 2005-12-17 | 15 | @ |  BUF | 28-17 | W | -8 | 35 | Ralph Wilson Stadium |
| 2005-12-24 | 16 | vs | OAK | 22-3 | W | 12.5 | 42.5 | Invesco Field at Mile High |
| 2005-12-31 | 17 | @ | SD | 23-7 | W | 7 | 44 | Qualcomm Stadium |
| 2006-01-14 | 19 | vs | NE | 27-13 | W | 3 | 44 | Invesco Field at Mile High |
| 2006-01-22 | 20 | vs |  PIT | 17-34 | L | 3.5 | 41 | Invesco Field at Mile High |
