| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-04 | 1 | @ | PHI | 20-24 | L | 8.5 | 47.5 | Lincoln Financial Field |
| 2025-09-14 | 2 | vs | NYG | 40-37 | W | 4.5 | 44.5 | AT&T Stadium |
| 2025-09-21 | 3 | @ | CHI | 14-31 | L | -1.5 | 49.5 | Soldier Field |
| 2025-09-28 | 4 | vs | GB | 40-40 | T | -7 | 47.5 | AT&T Stadium |
| 2025-10-05 | 5 | @ | NYJ | 37-22 | W | 1.5 | 48.5 | MetLife Stadium |
| 2025-10-12 | 6 | @ | CAR | 27-30 | L | -3 | 47.5 | Bank of America Stadium |
| 2025-10-19 | 7 | vs | WAS | 44-22 | W | 1.5 | 54.5 | AT&T Stadium |
| 2025-10-26 | 8 | @ | DEN | 24-44 | L | 3.5 | 51.5 | Empower Field at Mile High |
| 2025-11-03 | 9 | vs | ARI | 17-27 | L | 3.5 | 53.5 | AT&T Stadium |
| 2025-11-17 | 11 | @ | LV | 33-16 | W | -3.5 | 48.5 | Allegiant Stadium |
| 2025-11-23 | 12 | vs | PHI | 24-21 | W | -3 | 47.5 | AT&T Stadium |
| 2025-11-27 | 13 | vs | KC | 31-28 | W | -3.5 | 53.5 | AT&T Stadium |
| 2025-12-04 | 14 | @ | DET | 30-44 | L | 3.5 | 55.5 | Ford Field |
| 2025-12-14 | 15 | vs | MIN | 26-34 | L | 5.5 | 47.5 | AT&T Stadium |
| 2025-12-21 | 16 | vs | LAC | 17-34 | L | 1.5 | 50.5 | AT&T Stadium |
| 2025-12-25 | 17 | @ | WAS | 30-23 | W | -8.5 | 50.5 | FedExField |
| 2026-01-04 | 18 | @ | NYG | 17-34 | L | -3 | 50.5 | MetLife Stadium |
