| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | @ | CLE | 17-16 | W | -5.5 | 47.5 | FirstEnergy Stadium |
| 2025-09-14 | 2 | vs | JAX | 31-27 | W | 3.5 | 49.5 | Paycor Stadium |
| 2025-09-21 | 3 | @ | MIN | 10-48 | L | 3 | 41.5 | U.S. Bank Stadium |
| 2025-09-29 | 4 | @ | DEN | 3-28 | L | 7.5 | 44.5 | Empower Field at Mile High |
| 2025-10-05 | 5 | vs | DET | 24-37 | L | -10.5 | 49.5 | Paycor Stadium |
| 2025-10-12 | 6 | @ | GB | 18-27 | L | 14 | 44.5 | Lambeau Field |
| 2025-10-16 | 7 | vs | PIT | 33-31 | W | -5.5 | 45.5 | Paycor Stadium |
| 2025-10-26 | 8 | vs | NYJ | 38-39 | L | 5.5 | 43.5 | Paycor Stadium |
| 2025-11-02 | 9 | vs | CHI | 42-47 | L | -3 | 51.5 | Paycor Stadium |
| 2025-11-16 | 11 | @ | PIT | 12-34 | L | 5.5 | 48.5 | Acrisure Stadium |
| 2025-11-23 | 12 | vs | NE | 20-26 | L | -7.5 | 50.5 | Paycor Stadium |
| 2025-11-27 | 13 | @ | BAL | 32-14 | W | 7 | 52.5 | M&T Bank Stadium |
| 2025-12-07 | 14 | @ | BUF | 34-39 | L | 6 | 54.5 | New Era Field |
| 2025-12-14 | 15 | vs | BAL | 0-24 | L | -2.5 | 51.5 | Paycor Stadium |
| 2025-12-21 | 16 | @ | MIA | 45-21 | W | -3.5 | 48.5 | Hard Rock Stadium |
| 2025-12-28 | 17 | vs | ARI | 37-14 | W | 7 | 52.5 | Paycor Stadium |
| 2026-01-04 | 18 | vs | CLE | 18-20 | L | 9.5 | 47.5 | Paycor Stadium |
