| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | vs | TB | 20-23 | L | -1.5 | 47.5 | Mercedes-Benz Stadium |
| 2025-09-14 | 2 | @ | MIN | 22-6 | W | 3.5 | 44.5 | U.S. Bank Stadium |
| 2025-09-21 | 3 | @ | CAR | 0-30 | L | -5.5 | 44.5 | Bank of America Stadium |
| 2025-09-28 | 4 | vs | WAS | 34-27 | W | 2.5 | 43.5 | Mercedes-Benz Stadium |
| 2025-10-13 | 6 | vs | BUF | 24-14 | W | -3.5 | 49.5 | Mercedes-Benz Stadium |
| 2025-10-19 | 7 | @ | SF | 10-20 | L | 1.5 | 46.5 | Levi's Stadium |
| 2025-10-26 | 8 | vs | MIA | 10-34 | L | 7 | 44.5 | Mercedes-Benz Stadium |
| 2025-11-02 | 9 | @ | NE | 23-24 | L | 5.5 | 45.5 | Gillette Stadium |
| 2025-11-09 | 10 | @ | IND | 25-31 | L | 6.5 | 48.5 | Lucas Oil Stadium |
| 2025-11-16 | 11 | vs | CAR | 27-30 | L | 4.5 | 42.5 | Mercedes-Benz Stadium |
| 2025-11-23 | 12 | @ | NO | 24-10 | W | 1.5 | 41.5 | Mercedes-Benz Superdome |
| 2025-11-30 | 13 | @ | NYJ | 24-27 | L | -3 | 38.5 | MetLife Stadium |
| 2025-12-07 | 14 | vs | SEA | 9-37 | L | -7 | 44.5 | Mercedes-Benz Stadium |
| 2025-12-11 | 15 | @ | TB | 29-28 | W | 6 | 43.5 | Raymond James Stadium |
| 2025-12-21 | 16 | @ | ARI | 26-19 | W | -2.5 | 48.5 | State Farm Stadium |
| 2025-12-29 | 17 | vs | LA | 27-24 | W | -7.5 | 48.5 | Mercedes-Benz Stadium |
| 2026-01-04 | 18 | vs | NO | 19-17 | W | 4.5 | 43.5 | Mercedes-Benz Stadium |
