| 2009-09-13 | 1 | vs |  SF | 16-20 | L | 5 | 45.5 | University of Phoenix Stadium |
| 2009-09-20 | 2 | @ |  JAX | 31-17 | W | 3 | 42.5 | Jacksonville Municipal Stadium |
| 2009-09-27 | 3 | vs |  IND | 10-31 | L | 3 | 49 | University of Phoenix Stadium |
| 2009-10-11 | 5 | vs |  HOU | 28-21 | W | 5.5 | 50.5 | University of Phoenix Stadium |
| 2009-10-18 | 6 | @ |  SEA | 27-3 | W | 3 | 45.5 | Qwest Field |
| 2009-10-25 | 7 | @ |  NYG | 24-17 | W | 9 | 46.5 | Giants Stadium |
| 2009-11-01 | 8 | vs |  CAR | 21-34 | L | 10 | 43.5 | University of Phoenix Stadium |
| 2009-11-08 | 9 | @ |  CHI | 41-21 | W | 1 | 44.5 | Soldier Field |
| 2009-11-15 | 10 | vs | SEA | 31-20 | W | 9 | 46.5 | University of Phoenix Stadium |
| 2009-11-22 | 11 | @ |  STL | 21-13 | W | -9.5 | 46.5 | Edward Jones Dome |
| 2009-11-29 | 12 | @ |  TEN | 17-20 | L | 3.5 | 44.5 | LP Field |
| 2009-12-06 | 13 | vs |  MIN | 30-17 | W | -3.5 | 48 | University of Phoenix Stadium |
| 2009-12-14 | 14 | @ | SF | 9-24 | L | -4 | 44.5 | Candlestick Park |
| 2009-12-20 | 15 | @ |  DET | 31-24 | W | -14 | 46.5 | Ford Field |
| 2009-12-27 | 16 | vs | STL | 31-10 | W | 16 | 44 | University of Phoenix Stadium |
| 2010-01-03 | 17 | vs |  GB | 7-33 | L | 3 | 42 | University of Phoenix Stadium |
| 2010-01-10 | 18 | vs | GB | 51-45 | W | -2.5 | 48 | University of Phoenix Stadium |
| 2010-01-16 | 19 | @ |  NO | 14-45 | L | 7 | 57 | Louisiana Superdome |
