| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | @ | NO | 20-13 | W | -6 | 44.5 | Mercedes-Benz Superdome |
| 2025-09-14 | 2 | vs | CAR | 27-22 | W | 7 | 45.5 | State Farm Stadium |
| 2025-09-21 | 3 | @ | SF | 15-16 | L | 1.5 | 44.5 | Levi's Stadium |
| 2025-09-25 | 4 | vs | SEA | 20-23 | L | -1.5 | 43.5 | State Farm Stadium |
| 2025-10-05 | 5 | vs | TEN | 21-22 | L | 7.5 | 41.5 | State Farm Stadium |
| 2025-10-12 | 6 | @ | IND | 27-31 | L | 8.5 | 46.5 | Lucas Oil Stadium |
| 2025-10-19 | 7 | vs | GB | 23-27 | L | -7 | 44.5 | State Farm Stadium |
| 2025-11-03 | 9 | @ | DAL | 27-17 | W | 3.5 | 53.5 | AT&T Stadium |
| 2025-11-09 | 10 | @ | SEA | 22-44 | L | 7 | 44.5 | Lumen Field |
| 2025-11-16 | 11 | vs | SF | 22-41 | L | -3.5 | 48.5 | State Farm Stadium |
| 2025-11-23 | 12 | vs | JAX | 24-27 | L | -2.5 | 47.5 | State Farm Stadium |
| 2025-11-30 | 13 | @ | TB | 17-20 | L | 4.5 | 44.5 | Raymond James Stadium |
| 2025-12-07 | 14 | vs | LA | 17-45 | L | -9.5 | 49.5 | State Farm Stadium |
| 2025-12-14 | 15 | @ | HOU | 20-40 | L | 10.5 | 42.5 | NRG Stadium |
| 2025-12-21 | 16 | vs | ATL | 19-26 | L | -2.5 | 48.5 | State Farm Stadium |
| 2025-12-28 | 17 | @ | CIN | 14-37 | L | 7 | 52.5 | Paycor Stadium |
| 2026-01-04 | 18 | @ | LA | 20-37 | L | 14.5 | 49.5 | SoFi Stadium |
