| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | @ | DEN | 12-20 | L | 8.5 | 42.5 | Empower Field at Mile High |
| 2025-09-14 | 2 | vs | LA | 19-33 | L | -5.5 | 41.5 | Nissan Stadium |
| 2025-09-21 | 3 | vs | IND | 20-41 | L | -6 | 43.5 | Nissan Stadium |
| 2025-09-28 | 4 | @ | HOU | 0-26 | L | 7.5 | 39.5 | NRG Stadium |
| 2025-10-05 | 5 | @ | ARI | 22-21 | W | 7.5 | 41.5 | State Farm Stadium |
| 2025-10-12 | 6 | @ | LV | 10-20 | L | 3.5 | 41.5 | Allegiant Stadium |
| 2025-10-19 | 7 | vs | NE | 13-31 | L | -6.5 | 40.5 | Nissan Stadium |
| 2025-10-26 | 8 | @ | IND | 14-38 | L | 15.5 | 47.5 | Lucas Oil Stadium |
| 2025-11-02 | 9 | vs | LAC | 20-27 | L | -10 | 44.5 | Nissan Stadium |
| 2025-11-16 | 11 | vs | HOU | 13-16 | L | -5.5 | 37.5 | Nissan Stadium |
| 2025-11-23 | 12 | vs | SEA | 24-30 | L | -12.5 | 41.5 | Nissan Stadium |
| 2025-11-30 | 13 | vs | JAX | 3-25 | L | -6 | 42.5 | Nissan Stadium |
| 2025-12-07 | 14 | @ | CLE | 31-29 | W | 4.5 | 33.5 | FirstEnergy Stadium |
| 2025-12-14 | 15 | @ | SF | 24-37 | L | 12.5 | 44.5 | Levi's Stadium |
| 2025-12-21 | 16 | vs | KC | 26-9 | W | -3.5 | 37.5 | Nissan Stadium |
| 2025-12-28 | 17 | vs | NO | 26-34 | L | -1.5 | 39.5 | Nissan Stadium |
| 2026-01-04 | 18 | @ | JAX | 7-41 | L | 12.5 | 46.5 | TIAA Bank Stadium |
