| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | @ | NYJ | 34-32 | W | -3 | 37.5 | MetLife Stadium |
| 2025-09-14 | 2 | vs | SEA | 17-31 | L | 3.5 | 40.5 | Acrisure Stadium |
| 2025-09-21 | 3 | @ | NE | 21-14 | W | -1.5 | 44.5 | Gillette Stadium |
| 2025-09-28 | 4 | vs | MIN | 24-21 | W | -2.5 | 41.5 | Acrisure Stadium |
| 2025-10-12 | 6 | vs | CLE | 23-9 | W | 5.5 | 37.5 | Acrisure Stadium |
| 2025-10-16 | 7 | @ | CIN | 31-33 | L | -5.5 | 45.5 | Paycor Stadium |
| 2025-10-26 | 8 | vs | GB | 25-35 | L | -3 | 46.5 | Acrisure Stadium |
| 2025-11-02 | 9 | vs | IND | 27-20 | W | -3.5 | 51.5 | Acrisure Stadium |
| 2025-11-09 | 10 | @ | LAC | 10-25 | L | 3 | 45.5 | SoFi Stadium |
| 2025-11-16 | 11 | vs | CIN | 34-12 | W | 5.5 | 48.5 | Acrisure Stadium |
| 2025-11-23 | 12 | @ | CHI | 28-31 | L | 3 | 46.5 | Soldier Field |
| 2025-11-30 | 13 | vs | BUF | 7-26 | L | -3 | 44.5 | Acrisure Stadium |
| 2025-12-07 | 14 | @ | BAL | 27-22 | W | 5.5 | 43.5 | M&T Bank Stadium |
| 2025-12-15 | 15 | vs | MIA | 28-15 | W | 3 | 42.5 | Acrisure Stadium |
| 2025-12-21 | 16 | @ | DET | 29-24 | W | 7.5 | 52.5 | Ford Field |
| 2025-12-28 | 17 | @ | CLE | 6-13 | L | -4.5 | 35.5 | FirstEnergy Stadium |
| 2026-01-04 | 18 | vs | BAL | 26-24 | W | -4.5 | 41.5 | Acrisure Stadium |
| 2026-01-12 | 19 | vs | HOU | 6-30 | L | -3 | 38.5 | Acrisure Stadium |
