| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | vs | PIT | 32-34 | L | -3 | 37.5 | MetLife Stadium |
| 2025-09-14 | 2 | vs | BUF | 10-30 | L | -6 | 47.5 | MetLife Stadium |
| 2025-09-21 | 3 | @ | TB | 27-29 | L | 6.5 | 43.5 | Raymond James Stadium |
| 2025-09-29 | 4 | @ | MIA | 21-27 | L | 2.5 | 44.5 | Hard Rock Stadium |
| 2025-10-05 | 5 | vs | DAL | 22-37 | L | 1.5 | 48.5 | MetLife Stadium |
| 2025-10-12 | 6 | vs | DEN | 11-13 | L | -7.5 | 43.5 | MetLife Stadium |
| 2025-10-19 | 7 | vs | CAR | 6-13 | L | 1.5 | 39.5 | MetLife Stadium |
| 2025-10-26 | 8 | @ | CIN | 39-38 | W | 5.5 | 43.5 | Paycor Stadium |
| 2025-11-09 | 10 | vs | CLE | 27-20 | W | -1.5 | 37.5 | MetLife Stadium |
| 2025-11-13 | 11 | @ | NE | 14-27 | L | 12.5 | 43.5 | Gillette Stadium |
| 2025-11-23 | 12 | @ | BAL | 10-23 | L | 14 | 44.5 | M&T Bank Stadium |
| 2025-11-30 | 13 | vs | ATL | 27-24 | W | -3 | 38.5 | MetLife Stadium |
| 2025-12-07 | 14 | vs | MIA | 10-34 | L | -2.5 | 41.5 | MetLife Stadium |
| 2025-12-14 | 15 | @ | JAX | 20-48 | L | 13.5 | 40.5 | TIAA Bank Stadium |
| 2025-12-21 | 16 | @ | NO | 6-29 | L | 6.5 | 39.5 | Mercedes-Benz Superdome |
| 2025-12-28 | 17 | vs | NE | 10-42 | L | -12.5 | 42.5 | MetLife Stadium |
| 2026-01-04 | 18 | @ | BUF | 8-35 | L | 12.5 | 39.5 | New Era Field |
