| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | @ | WAS | 6-21 | L | 6 | 45.5 | FedExField |
| 2025-09-14 | 2 | @ | DAL | 37-40 | L | 4.5 | 44.5 | AT&T Stadium |
| 2025-09-21 | 3 | vs | KC | 9-22 | L | -6 | 44.5 | MetLife Stadium |
| 2025-09-28 | 4 | vs | LAC | 21-18 | W | -6 | 43.5 | MetLife Stadium |
| 2025-10-05 | 5 | @ | NO | 14-26 | L | 1.5 | 41.5 | Mercedes-Benz Superdome |
| 2025-10-09 | 6 | vs | PHI | 34-17 | W | -7 | 40.5 | MetLife Stadium |
| 2025-10-19 | 7 | @ | DEN | 32-33 | L | 7.5 | 39.5 | Empower Field at Mile High |
| 2025-10-26 | 8 | @ | PHI | 20-38 | L | 7 | 43.5 | Lincoln Financial Field |
| 2025-11-02 | 9 | vs | SF | 24-34 | L | -2.5 | 47.5 | MetLife Stadium |
| 2025-11-09 | 10 | @ | CHI | 20-24 | L | 4.5 | 45.5 | Soldier Field |
| 2025-11-16 | 11 | vs | GB | 20-27 | L | -7.5 | 41.5 | MetLife Stadium |
| 2025-11-23 | 12 | @ | DET | 27-34 | L | 14 | 50.5 | Ford Field |
| 2025-12-01 | 13 | @ | NE | 15-33 | L | 7 | 46.5 | Gillette Stadium |
| 2025-12-14 | 15 | vs | WAS | 21-29 | L | 2.5 | 46.5 | MetLife Stadium |
| 2025-12-21 | 16 | vs | MIN | 13-16 | L | -2.5 | 41.5 | MetLife Stadium |
| 2025-12-28 | 17 | @ | LV | 34-10 | W | -3 | 40.5 | Allegiant Stadium |
| 2026-01-04 | 18 | vs | DAL | 34-17 | W | -3 | 50.5 | MetLife Stadium |
