| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | vs | ARI | 13-20 | L | -6 | 44.5 | Mercedes-Benz Superdome |
| 2025-09-14 | 2 | vs | SF | 21-26 | L | -3 | 40.5 | Mercedes-Benz Superdome |
| 2025-09-21 | 3 | @ | SEA | 13-44 | L | 7.5 | 41.5 | Lumen Field |
| 2025-09-28 | 4 | @ | BUF | 19-31 | L | 15.5 | 48.5 | New Era Field |
| 2025-10-05 | 5 | vs | NYG | 26-14 | W | 1.5 | 41.5 | Mercedes-Benz Superdome |
| 2025-10-12 | 6 | vs | NE | 19-25 | L | -3.5 | 46.5 | Mercedes-Benz Superdome |
| 2025-10-19 | 7 | @ | CHI | 14-26 | L | 4.5 | 43.5 | Soldier Field |
| 2025-10-26 | 8 | vs | TB | 3-23 | L | -4.5 | 46.5 | Mercedes-Benz Superdome |
| 2025-11-02 | 9 | @ | LA | 10-34 | L | 14 | 44.5 | SoFi Stadium |
| 2025-11-09 | 10 | @ | CAR | 17-7 | W | 5.5 | 38.5 | Bank of America Stadium |
| 2025-11-23 | 12 | vs | ATL | 10-24 | L | 1.5 | 41.5 | Mercedes-Benz Superdome |
| 2025-11-30 | 13 | @ | MIA | 17-21 | L | 5.5 | 41.5 | Hard Rock Stadium |
| 2025-12-07 | 14 | @ | TB | 24-20 | W | 7.5 | 41.5 | Raymond James Stadium |
| 2025-12-14 | 15 | vs | CAR | 20-17 | W | -2.5 | 41.5 | Mercedes-Benz Superdome |
| 2025-12-21 | 16 | vs | NYJ | 29-6 | W | 6.5 | 39.5 | Mercedes-Benz Superdome |
| 2025-12-28 | 17 | @ | TEN | 34-26 | W | -1.5 | 39.5 | Nissan Stadium |
| 2026-01-04 | 18 | @ | ATL | 17-19 | L | 4.5 | 43.5 | Mercedes-Benz Stadium |
