| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | vs | LV | 13-20 | L | 2.5 | 44.5 | Gillette Stadium |
| 2025-09-14 | 2 | @ | MIA | 33-27 | W | 1.5 | 43.5 | Hard Rock Stadium |
| 2025-09-21 | 3 | vs | PIT | 14-21 | L | -1.5 | 44.5 | Gillette Stadium |
| 2025-09-28 | 4 | vs | CAR | 42-13 | W | 5.5 | 42.5 | Gillette Stadium |
| 2025-10-05 | 5 | @ | BUF | 23-20 | W | 7.5 | 49.5 | New Era Field |
| 2025-10-12 | 6 | @ | NO | 25-19 | W | -3.5 | 46.5 | Mercedes-Benz Superdome |
| 2025-10-19 | 7 | @ | TEN | 31-13 | W | -6.5 | 40.5 | Nissan Stadium |
| 2025-10-26 | 8 | vs | CLE | 32-13 | W | 7 | 40.5 | Gillette Stadium |
| 2025-11-02 | 9 | vs | ATL | 24-23 | W | 5.5 | 45.5 | Gillette Stadium |
| 2025-11-09 | 10 | @ | TB | 28-23 | W | 2.5 | 48.5 | Raymond James Stadium |
| 2025-11-13 | 11 | vs | NYJ | 27-14 | W | 12.5 | 43.5 | Gillette Stadium |
| 2025-11-23 | 12 | @ | CIN | 26-20 | W | -7.5 | 50.5 | Paycor Stadium |
| 2025-12-01 | 13 | vs | NYG | 33-15 | W | 7 | 46.5 | Gillette Stadium |
| 2025-12-14 | 15 | vs | BUF | 31-35 | L | -2.5 | 49.5 | Gillette Stadium |
| 2025-12-21 | 16 | @ | BAL | 28-24 | W | 3.5 | 48.5 | M&T Bank Stadium |
| 2025-12-28 | 17 | @ | NYJ | 42-10 | W | -12.5 | 42.5 | MetLife Stadium |
| 2026-01-04 | 18 | vs | MIA | 38-10 | W | 14 | 44.5 | Gillette Stadium |
| 2026-01-11 | 19 | vs | LAC | 16-3 | W | 3.5 | 45.5 | Gillette Stadium |
| 2026-01-18 | 20 | vs | HOU | 28-16 | W | 3 | 40.5 | Gillette Stadium |
| 2026-01-25 | 21 | @ | DEN | 10-7 | W | -3.5 | 43.5 | Empower Field at Mile High |
| 2026-02-08 | 22 | vs | SEA | 13-29 | L | -4.5 | 45.5 | Levi's Stadium |
