| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-08 | 1 | @ | CHI | 27-24 | W | -1.5 | 43.5 | Soldier Field |
| 2025-09-14 | 2 | vs | ATL | 6-22 | L | 3.5 | 44.5 | U.S. Bank Stadium |
| 2025-09-21 | 3 | vs | CIN | 48-10 | W | 3 | 41.5 | U.S. Bank Stadium |
| 2025-09-28 | 4 | @ | PIT | 21-24 | L | -2.5 | 41.5 | Acrisure Stadium |
| 2025-10-05 | 5 | @ | CLE | 21-17 | W | -3.5 | 35.5 | FirstEnergy Stadium |
| 2025-10-19 | 7 | vs | PHI | 22-28 | L | -2.5 | 43.5 | U.S. Bank Stadium |
| 2025-10-23 | 8 | @ | LAC | 10-37 | L | 3 | 45.5 | SoFi Stadium |
| 2025-11-02 | 9 | @ | DET | 27-24 | W | 9.5 | 47.5 | Ford Field |
| 2025-11-09 | 10 | vs | BAL | 19-27 | L | -4.5 | 48.5 | U.S. Bank Stadium |
| 2025-11-16 | 11 | vs | CHI | 17-19 | L | 3 | 47.5 | U.S. Bank Stadium |
| 2025-11-23 | 12 | @ | GB | 6-23 | L | 6.5 | 41.5 | Lambeau Field |
| 2025-11-30 | 13 | @ | SEA | 0-26 | L | 12.5 | 42.5 | Lumen Field |
| 2025-12-07 | 14 | vs | WAS | 31-0 | W | -1.5 | 43.5 | U.S. Bank Stadium |
| 2025-12-14 | 15 | @ | DAL | 34-26 | W | 5.5 | 47.5 | AT&T Stadium |
| 2025-12-21 | 16 | @ | NYG | 16-13 | W | -2.5 | 41.5 | MetLife Stadium |
| 2025-12-25 | 17 | vs | DET | 23-10 | W | -7 | 45.5 | U.S. Bank Stadium |
| 2026-01-04 | 18 | vs | GB | 16-3 | W | 12.5 | 37.5 | U.S. Bank Stadium |
