| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | @ | IND | 8-33 | L | 1.5 | 47.5 | Lucas Oil Stadium |
| 2025-09-14 | 2 | vs | NE | 27-33 | L | 1.5 | 43.5 | Hard Rock Stadium |
| 2025-09-18 | 3 | @ | BUF | 21-31 | L | 12.5 | 50.5 | New Era Field |
| 2025-09-29 | 4 | vs | NYJ | 27-21 | W | 2.5 | 44.5 | Hard Rock Stadium |
| 2025-10-05 | 5 | @ | CAR | 24-27 | L | -1.5 | 44.5 | Bank of America Stadium |
| 2025-10-12 | 6 | vs | LAC | 27-29 | L | -3.5 | 45.5 | Hard Rock Stadium |
| 2025-10-19 | 7 | @ | CLE | 6-31 | L | 2.5 | 34.5 | FirstEnergy Stadium |
| 2025-10-26 | 8 | @ | ATL | 34-10 | W | 7 | 44.5 | Mercedes-Benz Stadium |
| 2025-10-30 | 9 | vs | BAL | 6-28 | L | -7.5 | 51.5 | Hard Rock Stadium |
| 2025-11-09 | 10 | vs | BUF | 30-13 | W | -8.5 | 50.5 | Hard Rock Stadium |
| 2025-11-16 | 11 | vs | WAS | 16-13 | W | 2.5 | 47.5 | Hard Rock Stadium |
| 2025-11-30 | 13 | vs | NO | 21-17 | W | 5.5 | 41.5 | Hard Rock Stadium |
| 2025-12-07 | 14 | @ | NYJ | 34-10 | W | -2.5 | 41.5 | MetLife Stadium |
| 2025-12-15 | 15 | @ | PIT | 15-28 | L | 3 | 42.5 | Acrisure Stadium |
| 2025-12-21 | 16 | vs | CIN | 21-45 | L | -3.5 | 48.5 | Hard Rock Stadium |
| 2025-12-28 | 17 | vs | TB | 20-17 | W | -5.5 | 44.5 | Hard Rock Stadium |
| 2026-01-04 | 18 | @ | NE | 10-38 | L | 14 | 44.5 | Gillette Stadium |
