| Date | Wk | Side | Opponent | Score | Result | Spread | O/U | Stadium |
|---|---|---|---|---|---|---|---|---|
| 2025-09-07 | 1 | @ | NE | 20-13 | W | 2.5 | 44.5 | Gillette Stadium |
| 2025-09-15 | 2 | vs | LAC | 9-20 | L | -3.5 | 46.5 | Allegiant Stadium |
| 2025-09-21 | 3 | @ | WAS | 24-41 | L | 2.5 | 43.5 | FedExField |
| 2025-09-28 | 4 | vs | CHI | 24-25 | L | 1.5 | 47.5 | Allegiant Stadium |
| 2025-10-05 | 5 | @ | IND | 6-40 | L | 7 | 46.5 | Lucas Oil Stadium |
| 2025-10-12 | 6 | vs | TEN | 20-10 | W | 3.5 | 41.5 | Allegiant Stadium |
| 2025-10-19 | 7 | @ | KC | 0-31 | L | 13.5 | 44.5 | GEHA Field at Arrowhead Stadium |
| 2025-11-02 | 9 | vs | JAX | 29-30 | L | -2.5 | 43.5 | Allegiant Stadium |
| 2025-11-06 | 10 | @ | DEN | 7-10 | L | 9.5 | 42.5 | Empower Field at Mile High |
| 2025-11-17 | 11 | vs | DAL | 16-33 | L | -3.5 | 48.5 | Allegiant Stadium |
| 2025-11-23 | 12 | vs | CLE | 10-24 | L | 3 | 35.5 | Allegiant Stadium |
| 2025-11-30 | 13 | @ | LAC | 14-31 | L | 10 | 40.5 | SoFi Stadium |
| 2025-12-07 | 14 | vs | DEN | 17-24 | L | -8.5 | 40.5 | Allegiant Stadium |
| 2025-12-14 | 15 | @ | PHI | 0-31 | L | 12.5 | 37.5 | Lincoln Financial Field |
| 2025-12-21 | 16 | @ | HOU | 21-23 | L | 14.5 | 39.5 | NRG Stadium |
| 2025-12-28 | 17 | vs | NYG | 10-34 | L | -3 | 40.5 | Allegiant Stadium |
| 2026-01-04 | 18 | vs | KC | 14-12 | W | -3.5 | 36.5 | Allegiant Stadium |
